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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-2-23
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pubmed:abstractText |
The rare t(9;11)(p22;p15) translocation is associated with adult acute myeloid leukemia (AML) with immature forms. We report a novel fusion of the NUP98 and LEDGF genes in a pediatric AML with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes exhibiting the same chromosomal rearrangement. Fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR) studies identified the chimeric transcript product of in-frame fusion of NUP98 exon 8 to LEDGF exon 4.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
467-70
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15725483-Artificial Gene Fusion,
pubmed-meshheading:15725483-Child, Preschool,
pubmed-meshheading:15725483-Chromosome Mapping,
pubmed-meshheading:15725483-Chromosomes, Human, Pair 11,
pubmed-meshheading:15725483-Chromosomes, Human, Pair 22,
pubmed-meshheading:15725483-Female,
pubmed-meshheading:15725483-Humans,
pubmed-meshheading:15725483-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15725483-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15725483-Karyotyping,
pubmed-meshheading:15725483-Leukemia, Myeloid, Acute,
pubmed-meshheading:15725483-Nuclear Pore Complex Proteins,
pubmed-meshheading:15725483-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15725483-Translocation, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia.
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pubmed:affiliation |
Dipartimento di Ematologia ed Oncologia Pediatrica, Istituto Giannina Gaslini, L.go G. Gaslini 5, 16147 Genova, Italy.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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