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rdf:type |
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lifeskim:mentions |
umls-concept:C0011777,
umls-concept:C0016026,
umls-concept:C0017262,
umls-concept:C0024880,
umls-concept:C0065180,
umls-concept:C0171302,
umls-concept:C0185117,
umls-concept:C0333516,
umls-concept:C0591833,
umls-concept:C1257792,
umls-concept:C1280500,
umls-concept:C1333536,
umls-concept:C1707455,
umls-concept:C1743827,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2005-2-23
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pubmed:abstractText |
It has been shown that many antihistamines may have anti-inflammatory activity in addition to being H1 antagonists. Mizolastine (MIZ), a novel antihistamine, might also have anti-angiogenesis properties. In this study, we investigated the influence of MIZ on proangiogenesis factors, vascular endothelial cell growth factor (VEGF), tumour necrosis factor (TNF)-alpha and keratinocyte-derived chemokine (KC) in murine mast cells by using ELISA and RT-PCR, as compared with dexamethasone (DEX) and loratadine (LOR). Our results show that MIZ is effective in the inhibition of KC, VEGF and TNF-alpha release induced by an IgE-dependent mechanism, in a time- and dose-dependent manner. The differences between the inhibitory effects of the three drugs on these proangiogenic factors were rather subtle. Semiquantitative analysis using RT-PCR showed that the three drugs significantly reduced VEGF165, VEGF120, TNF-alpha and KC mRNA expression. Statistical results revealed that the effect of DEX on VEGF165 mRNA was different from that of MIZ or LOR (P < 0.01) and the differences between the three drugs on VEGF120, TNF-alpha and KC mRNA were not statistically significant (P > 0.05). These findings raise the possibility that MIZ can mediate anti-angiogenesis activity and that the effect may depend not only on the inhibition on the levels of cytokine proteins but also at the mRNA level.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inducing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H1 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Loratadine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/keratinocyte-derived chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/mizolastine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0307-6938
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-70
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15725247-Angiogenesis Inducing Agents,
pubmed-meshheading:15725247-Animals,
pubmed-meshheading:15725247-Anti-Inflammatory Agents,
pubmed-meshheading:15725247-Benzimidazoles,
pubmed-meshheading:15725247-Cells, Cultured,
pubmed-meshheading:15725247-Chemokine CXCL1,
pubmed-meshheading:15725247-Chemokines,
pubmed-meshheading:15725247-Chemokines, CXC,
pubmed-meshheading:15725247-Cytokines,
pubmed-meshheading:15725247-Dexamethasone,
pubmed-meshheading:15725247-Dose-Response Relationship, Drug,
pubmed-meshheading:15725247-Gene Expression Regulation,
pubmed-meshheading:15725247-Histamine H1 Antagonists,
pubmed-meshheading:15725247-Loratadine,
pubmed-meshheading:15725247-Mast Cells,
pubmed-meshheading:15725247-Mice,
pubmed-meshheading:15725247-RNA, Messenger,
pubmed-meshheading:15725247-Receptors, IgE,
pubmed-meshheading:15725247-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15725247-Tumor Necrosis Factor-alpha,
pubmed-meshheading:15725247-Vascular Endothelial Growth Factor A
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pubmed:year |
2005
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pubmed:articleTitle |
The effect of mizolastine on expression of vascular endothelial cell growth factor, tumour necrosis factor-alpha and keratinocyte-derived chemokine in murine mast cells, compared with dexamethasone and loratadine.
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pubmed:affiliation |
Institute of Dermatology & Department of Dermatology at no. 1 Hospital, Anhui Medical University, Hefei, Anhui, PR China.
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pubmed:publicationType |
Journal Article,
Comparative Study
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