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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
8
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pubmed:dateCreated |
2005-3-1
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|
pubmed:abstractText |
Calcineurin (CnA) is important in the regulation of myocardial hypertrophy. We demonstrated that targeted proteolysis of the CnA autoinhibitory domain under pathological myocardial workload leads to increased CnA activity in human myocardium. Here, we investigated the proteolytic mechanism leading to activation of CnA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
|
pubmed:issn |
1524-4539
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1045-53
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15723976-Active Transport, Cell Nucleus,
pubmed-meshheading:15723976-Amino Acid Sequence,
pubmed-meshheading:15723976-Animals,
pubmed-meshheading:15723976-Animals, Newborn,
pubmed-meshheading:15723976-Calcineurin,
pubmed-meshheading:15723976-Calpain,
pubmed-meshheading:15723976-Cardiomegaly,
pubmed-meshheading:15723976-Cell Extracts,
pubmed-meshheading:15723976-Cell Nucleus,
pubmed-meshheading:15723976-Cells, Cultured,
pubmed-meshheading:15723976-Enzyme Activation,
pubmed-meshheading:15723976-Frozen Sections,
pubmed-meshheading:15723976-Humans,
pubmed-meshheading:15723976-Hydrolysis,
pubmed-meshheading:15723976-Molecular Sequence Data,
pubmed-meshheading:15723976-Myocardium,
pubmed-meshheading:15723976-Myocytes, Cardiac,
pubmed-meshheading:15723976-Phosphoric Monoester Hydrolases,
pubmed-meshheading:15723976-Proteins,
pubmed-meshheading:15723976-Rats,
pubmed-meshheading:15723976-Rats, Wistar,
pubmed-meshheading:15723976-Transcription, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Targeted proteolysis sustains calcineurin activation.
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pubmed:affiliation |
Department of Medicine, University of Wuerzburg, Wuerzburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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