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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-3-8
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pubmed:abstractText |
Alpha-adrenergic receptor (alphaAR)-stimulated hypertrophy in adult rat ventricular myocytes is mediated by reactive oxygen species-dependent activation of the Ras-Raf-MEK1/2-ERK1/2 signaling pathway. Because Ras is known to have redox-sensitive cysteine residues, we tested the hypothesis that alphaAR-stimulated hypertrophic signaling is mediated via oxidative modification of Ras thiols.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Dicarboxylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Dithiothreitol,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins p21(ras),
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 90-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfhydryl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Thioredoxins,
http://linkedlifedata.com/resource/pubmed/chemical/azelaic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1192-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15723974-Animals,
pubmed-meshheading:15723974-Catalase,
pubmed-meshheading:15723974-Cysteine,
pubmed-meshheading:15723974-Dicarboxylic Acids,
pubmed-meshheading:15723974-Dithiothreitol,
pubmed-meshheading:15723974-Enzyme Activation,
pubmed-meshheading:15723974-Heart Ventricles,
pubmed-meshheading:15723974-Hypertrophy,
pubmed-meshheading:15723974-MAP Kinase Kinase 1,
pubmed-meshheading:15723974-MAP Kinase Kinase 2,
pubmed-meshheading:15723974-Male,
pubmed-meshheading:15723974-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:15723974-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:15723974-Myocytes, Cardiac,
pubmed-meshheading:15723974-Norepinephrine,
pubmed-meshheading:15723974-Oxidation-Reduction,
pubmed-meshheading:15723974-Peroxidase,
pubmed-meshheading:15723974-Phosphorylation,
pubmed-meshheading:15723974-Protein Processing, Post-Translational,
pubmed-meshheading:15723974-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:15723974-Rats,
pubmed-meshheading:15723974-Rats, Sprague-Dawley,
pubmed-meshheading:15723974-Reactive Oxygen Species,
pubmed-meshheading:15723974-Receptors, Adrenergic, alpha,
pubmed-meshheading:15723974-Recombinant Fusion Proteins,
pubmed-meshheading:15723974-Ribosomal Protein S6 Kinases, 90-kDa,
pubmed-meshheading:15723974-Sarcomeres,
pubmed-meshheading:15723974-Signal Transduction,
pubmed-meshheading:15723974-Sulfhydryl Compounds,
pubmed-meshheading:15723974-Thioredoxins
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pubmed:year |
2005
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pubmed:articleTitle |
Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras.
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pubmed:affiliation |
Cardiovascular Medicine Section, Department of Medicine, and the Myocardial and Vascular Biology Units, Boston University Medical Center, Boston, Mass 02118, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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