Source:http://linkedlifedata.com/resource/pubmed/id/15721212
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-2-21
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| pubmed:abstractText |
Striatal dopamine D2/D3 receptors have been suggested to play a role in pain sensitivity and placebo effect. We studied whether the association of dopamine D2/D3 receptor binding potential (BP) with sensory thresholds is specific to the modality of pain, and whether striatal dopamine D2/D3 receptor BP predicts the magnitude of placebo analgesia. Pain and tactile thresholds, and placebo analgesia were assessed in eight healthy human male subjects who had previously participated in a dopamine D2/D3 receptor positron emission tomography study with [11C]raclopride. The results show that the cutaneous heat pain threshold was inversely correlated with dopamine D2/D3 receptor BP in the right putamen, but responses to tactile stimulation did not correlate with striatal dopamine D2/D3 receptor BP. Placebo-induced elevation of the heat pain threshold did not correlate with striatal dopamine D2/D3 receptor BP. These results suggest that the influence of striatal dopamine D2/D3 receptors on sensory thresholds is selective for the modality of pain. Moreover, striatal dopamine D2/D3 receptor BP appears not to predict individual's analgesic response to placebo.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DRD3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Raclopride,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D3
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0304-3940
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
376
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
149-53
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15721212-Adult,
pubmed-meshheading:15721212-Analgesia,
pubmed-meshheading:15721212-Binding, Competitive,
pubmed-meshheading:15721212-Corpus Striatum,
pubmed-meshheading:15721212-Dopamine Antagonists,
pubmed-meshheading:15721212-Functional Laterality,
pubmed-meshheading:15721212-Humans,
pubmed-meshheading:15721212-Hyperalgesia,
pubmed-meshheading:15721212-Male,
pubmed-meshheading:15721212-Pain,
pubmed-meshheading:15721212-Pain Threshold,
pubmed-meshheading:15721212-Physical Stimulation,
pubmed-meshheading:15721212-Placebo Effect,
pubmed-meshheading:15721212-Putamen,
pubmed-meshheading:15721212-Raclopride,
pubmed-meshheading:15721212-Receptors, Dopamine D2,
pubmed-meshheading:15721212-Receptors, Dopamine D3,
pubmed-meshheading:15721212-Sensory Thresholds,
pubmed-meshheading:15721212-Touch
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| pubmed:year |
2005
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| pubmed:articleTitle |
Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia.
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| pubmed:affiliation |
Department of Physiology, University of Turku, Turku, Finland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|