| pubmed-article:15718388 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15718388 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:15718388 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:15718388 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:15718388 | lifeskim:mentions | umls-concept:C0044707 | lld:lifeskim |
| pubmed-article:15718388 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:15718388 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15718388 | pubmed:dateCreated | 2005-5-11 | lld:pubmed |
| pubmed-article:15718388 | pubmed:abstractText | The syndrome of apparent mineralocorticoid excess (SAME) is an autosomal recessive form of salt-sensitive hypertension caused by deficiency of the kidney type 2 11beta-hydroxysteroid dehydrogenase (11betaHSD2). In this disorder, cortisol is not inactivated by 11betaHSD2, occupies mineralocorticoid receptors (MRs), and causes excessive sodium retention and hypertension. In renal medulla, prostaglandins derived from cyclooxygenase-2 (COX-2) stimulate sodium and water excretion, and renal medullary COX-2 expression increases after mineralocorticoid administration. We investigated whether medullary COX-2 also increases in rats with 11betaHSD2 inhibition and examined its possible role in the development of hypertension. 11betaHSD2 inhibition increased medullary and decreased cortical COX-2 expression in adult rats and induced high blood pressure in high-salt-treated rats. COX-2 inhibition had no effect on blood pressure in control animals but further increased blood pressure in high-salt-treated rats with 11betaHSD2 inhibition. COX-1 inhibition had no effect on blood pressure in either control or experimental animals. 11betaHSD2 inhibition also led to medullary COX-2 increase and cortical COX-2 decrease in weaning rats, primarily through activation of MRs. In the suckling rats, medullary COX-2 expression was very low, consistent with a urinary concentrating defect. 11betaHSD2 inhibition had no effect on either cortical or medullary COX-2 expression in the suckling rats, consistent with low levels of circulating corticosterone in these animals. These data indicate that COX-2 plays a modulating role in the development of hypertension due to 11betaHSD2 deficiency and that 11betaHSD2 regulates renal COX-2 expression by preventing glucocorticoid access to MRs during postnatal development. | lld:pubmed |
| pubmed-article:15718388 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15718388 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15718388 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15718388 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15718388 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15718388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15718388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15718388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15718388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15718388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15718388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15718388 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15718388 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15718388 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:15718388 | pubmed:author | pubmed-author:YaoBingB | lld:pubmed |
| pubmed-article:15718388 | pubmed:author | pubmed-author:HarrisRaymond... | lld:pubmed |
| pubmed-article:15718388 | pubmed:author | pubmed-author:ZhangMing-Zhi... | lld:pubmed |
| pubmed-article:15718388 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15718388 | pubmed:volume | 288 | lld:pubmed |
| pubmed-article:15718388 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15718388 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15718388 | pubmed:pagination | R1767-73 | lld:pubmed |
| pubmed-article:15718388 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15718388 | pubmed:meshHeading | pubmed-meshheading:15718388... | lld:pubmed |
| pubmed-article:15718388 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15718388 | pubmed:articleTitle | Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. | lld:pubmed |
| pubmed-article:15718388 | pubmed:affiliation | George O'Brien Center for Kidney and Urologic Diseases and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-4794, USA. | lld:pubmed |
| pubmed-article:15718388 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15718388 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15718388 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15718388 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15718388 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:25117 | entrezgene:pubmed | pubmed-article:15718388 | lld:entrezgene |
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