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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-2-17
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pubmed:abstractText |
Lipopolysaccharide (LPS) is the primary mediator of gram-negative sepsis; it induces the production of macrophage-derived cytokines. It has been shown that bikunin, a Kunitz-type protease inhibitor, inhibits LPS-induced cytokine expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:InagakiKiyokazuK,
pubmed-author:KanayamaNaohiroN,
pubmed-author:KobayashiHiroshiH,
pubmed-author:KondoToshiharuT,
pubmed-author:KuritaNoriyukiN,
pubmed-author:MatsuzakiHidenoriH,
pubmed-author:SekinoHideoH,
pubmed-author:SuzukiMikaM,
pubmed-author:TeraoToshihikoT,
pubmed-author:WakaharaKiyoshiK,
pubmed-author:YagyuTatsuoT
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pubmed:issnType |
Print
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pubmed:day |
15
|
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pubmed:volume |
191
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
930-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15717269-Animals,
pubmed-meshheading:15717269-Cells, Cultured,
pubmed-meshheading:15717269-Down-Regulation,
pubmed-meshheading:15717269-Inflammation,
pubmed-meshheading:15717269-Interleukin-1,
pubmed-meshheading:15717269-Lipopolysaccharides,
pubmed-meshheading:15717269-Macrophage Activation,
pubmed-meshheading:15717269-Macrophages, Peritoneal,
pubmed-meshheading:15717269-Membrane Glycoproteins,
pubmed-meshheading:15717269-Mice,
pubmed-meshheading:15717269-Mice, Inbred C57BL,
pubmed-meshheading:15717269-Mice, Knockout,
pubmed-meshheading:15717269-Serine Proteinase Inhibitors,
pubmed-meshheading:15717269-Trypsin Inhibitor, Kunitz Soybean,
pubmed-meshheading:15717269-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophages.
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pubmed:affiliation |
NetForce Co., Ltd., Aichi, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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