Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-2-17
pubmed:abstractText
The aims of this study were to estimate the incidences of BCR/ABL, MLL, TEL/AML1 rearrangements, and p16 deletions in childhood acute lymphoblastic leukemia (ALL), to identify new abnormalities, and to demonstrate the usefulness of interphase fluorescence in situ hybridization (FISH). We performed G-banding analysis and FISH using probes for BCR/ABL, MLL, TEL/AML1 rearrangements, and p16 deletions on 65 childhood ALL patients diagnosed and uniformly treated at a single hospital. Gene rearrangements were identified in 73.8% of the patients using the combination of G-banding and FISH, while the chromosomal abnormalities were identified in 49.2% using G-banding alone. Gene rearrangements were disclosed by FISH in 24 (72.7%) of 33 patients with normal karyotype or no mitotic cell in G-banding. Among the gene rearrangements detected by FISH, the most common gene rearrangement was p16 deletion (20.3%) and the incidences of others were 14.1% for TEL/AML1, 11.3% for MLL, and 1.8% for BCR/ABL translocations. Infrequent or new aberrations such as AML1 amplification, MLL deletion, ABL deletion, and TEL/AML1 fusion with AML1 deletion were also observed. We established the rough incidences of gene rearrangements in childhood ALL, found new abnormalities and demonstrated the diagnostic capability of interphase FISH to identify cryptic chromosome aberrations.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-10419898, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-10451708, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-10477677, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-10482981, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-10583273, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-10641030, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-10756360, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-10914938, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-11154239, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-11241794, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-11343784, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-11426627, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-11516105, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-11564064, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-11579464, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-11952819, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-12550760, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-7692945, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-8595153, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-8639909, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-8704231, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-8943861, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9028935, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9041193, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9166859, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9226156, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9305598, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9359534, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9593287, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9639410, http://linkedlifedata.com/resource/pubmed/commentcorrection/15716599-9824651
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1011-8934
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-41
pubmed:dateRevised
2010-9-20
pubmed:meshHeading
pubmed-meshheading:15716599-Adolescent, pubmed-meshheading:15716599-Child, pubmed-meshheading:15716599-Child, Preschool, pubmed-meshheading:15716599-Chromosome Aberrations, pubmed-meshheading:15716599-Chromosome Banding, pubmed-meshheading:15716599-Core Binding Factor Alpha 2 Subunit, pubmed-meshheading:15716599-Cyclin-Dependent Kinase Inhibitor p16, pubmed-meshheading:15716599-DNA-Binding Proteins, pubmed-meshheading:15716599-Female, pubmed-meshheading:15716599-Fusion Proteins, bcr-abl, pubmed-meshheading:15716599-Gene Deletion, pubmed-meshheading:15716599-Gene Rearrangement, pubmed-meshheading:15716599-Humans, pubmed-meshheading:15716599-In Situ Hybridization, Fluorescence, pubmed-meshheading:15716599-Infant, pubmed-meshheading:15716599-Interphase, pubmed-meshheading:15716599-Male, pubmed-meshheading:15716599-Myeloid-Lymphoid Leukemia Protein, pubmed-meshheading:15716599-Oncogene Proteins, Fusion, pubmed-meshheading:15716599-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:15716599-Proto-Oncogenes, pubmed-meshheading:15716599-Transcription Factors, pubmed-meshheading:15716599-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
Molecular cytogenetic analysis of gene rearrangements in childhood acute lymphoblastic leukemia.
pubmed:affiliation
Department of Laboratory Medicine, Sungkyunkwan University, School of Medicine, Seoul, Korea.
pubmed:publicationType
Journal Article