Source:http://linkedlifedata.com/resource/pubmed/id/15715499
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2005-2-17
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pubmed:abstractText |
2-Alkylamino-substituted-1,4-benzoxazine derivatives, a new class of potential neuroprotective agents, were synthesized and examined for their intrinsic cytotoxicity and their capacity to inhibit oxidative stress-mediated neuronal degeneration in vitro. Through structure-activity relationship studies, the 3,3-diphenyl-substituted-1,4-benzoxazine derivative 3l was identified as the optimal candidate, owing to its potent neuroprotective activity, without the manifestation of intrinsic cytotoxicity. Accordingly, 3l proved to be effective in an animal model of excitotoxic lesions in newborn mice.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1282-6
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pubmed:meshHeading |
pubmed-meshheading:15715499-Animals,
pubmed-meshheading:15715499-Animals, Newborn,
pubmed-meshheading:15715499-Benzoxazines,
pubmed-meshheading:15715499-Cell Line,
pubmed-meshheading:15715499-Cerebral Palsy,
pubmed-meshheading:15715499-Disease Models, Animal,
pubmed-meshheading:15715499-Hippocampus,
pubmed-meshheading:15715499-Mice,
pubmed-meshheading:15715499-Nerve Degeneration,
pubmed-meshheading:15715499-Neuroprotective Agents,
pubmed-meshheading:15715499-Oxidative Stress,
pubmed-meshheading:15715499-Reactive Oxygen Species,
pubmed-meshheading:15715499-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
Novel 2-alkylamino-1,4-benzoxazine derivatives as potent neuroprotective agents: structure-activity relationship studies.
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pubmed:affiliation |
UMR 8638 CNRS - Université René Descartes, Synthèse et Structure de Molécules d'Intérêt Pharmacologique, Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75270 Paris Cedex 06, France.
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pubmed:publicationType |
Journal Article
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