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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-2-17
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pubmed:abstractText |
Parenteral nutrition (PN) decreases gut-associated lymphoid tissue (GALT), the intestinal IgA stimulating cytokines IL-4 and IL-10 in gut homogenates, intestinal IgA levels and the expression of Peyer patch (PP) mucosal cellular adhesion molecule-1 (MAdCAM-1), an adhesion molecule found on the high endothelial venules of PP and other tissues. IL-4 in PP stimulates MAdCAM expression in vitro. MAdCAM-1 blockade with MECA-367 reduces GALT cell populations to PN levels but maintains intestinal IgA levels if the animals are chow fed. This study compares IL-4 levels in PP of chow and PN fed mice and measures the effects of MAdCAM blockade on IL-4 and IL-10 levels in gut homogenates of chow fed mice. We hypothesized that in vivo IL-4 levels drop in PP of PN fed mice and IL-4 and IL-10 levels are maintained after MAdCAM-1 blockade in chow fed mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0148-6071
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
44-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15715273-Animals,
pubmed-meshheading:15715273-Antibodies, Monoclonal,
pubmed-meshheading:15715273-Cell Adhesion Molecules,
pubmed-meshheading:15715273-Enteral Nutrition,
pubmed-meshheading:15715273-Immunity, Mucosal,
pubmed-meshheading:15715273-Immunoglobulin A,
pubmed-meshheading:15715273-Immunoglobulins,
pubmed-meshheading:15715273-Interleukin-10,
pubmed-meshheading:15715273-Interleukin-4,
pubmed-meshheading:15715273-Intestinal Mucosa,
pubmed-meshheading:15715273-Male,
pubmed-meshheading:15715273-Mice,
pubmed-meshheading:15715273-Mice, Inbred ICR,
pubmed-meshheading:15715273-Mucoproteins,
pubmed-meshheading:15715273-Parenteral Nutrition,
pubmed-meshheading:15715273-Peyer's Patches,
pubmed-meshheading:15715273-Random Allocation
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pubmed:articleTitle |
Enteral feeding preserves gut Th-2 cytokines despite mucosal cellular adhesion molecule-1 blockade.
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pubmed:affiliation |
Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital Madison, Wisconsin, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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