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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-2-16
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pubmed:abstractText |
The radiosynthesis and the radiopharmacological evaluation of pyrazolo steroid 2'-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11beta,17alpha-dihydroxy-pregn-4-eno[3,2-c]pyrazole [18F]-2 is described. The radiolabeling was accomplished in 3-4% decay-corrected radiochemical yield within 80 min at an specific radioactivity of 0.8-1.2 Ci/micromol. Biodistribution studies in male Wistar rats showed an initial brain uptake of 0.25+/-0.03% ID/g after 5 min, which remained constant over 60 min. The radiopharmacological evaluation of compound [18F]-2 was completed with autoradiography using rat brain sections and micro-PET imaging.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1303-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15713375-Animals,
pubmed-meshheading:15713375-Autoradiography,
pubmed-meshheading:15713375-Brain,
pubmed-meshheading:15713375-Drug Stability,
pubmed-meshheading:15713375-Fluorine Radioisotopes,
pubmed-meshheading:15713375-Isotope Labeling,
pubmed-meshheading:15713375-Ligands,
pubmed-meshheading:15713375-Male,
pubmed-meshheading:15713375-Molecular Conformation,
pubmed-meshheading:15713375-Positron-Emission Tomography,
pubmed-meshheading:15713375-Pregnanes,
pubmed-meshheading:15713375-Pyrazoles,
pubmed-meshheading:15713375-Radioligand Assay,
pubmed-meshheading:15713375-Rats,
pubmed-meshheading:15713375-Rats, Wistar,
pubmed-meshheading:15713375-Receptors, Glucocorticoid,
pubmed-meshheading:15713375-Structure-Activity Relationship,
pubmed-meshheading:15713375-Tissue Distribution
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis and radiopharmacological evaluation of 2'-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11beta,17alpha-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET).
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pubmed:affiliation |
Institut für Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf e.V., PO Box 51 01 19, D-01314 Dresden, Germany. f.wuest@fz-rossendorf.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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