Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-3-14
pubmed:abstractText
Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division. In most cases where the tetraploidy checkpoint has been observed cell division was perturbed by anti-cytoskeleton drug treatments. However, other evidence argues against the existence of a tetraploidy checkpoint. Cells that have failed to divide differ from normal cells in having two nuclei, two centrosomes, a decreased surface to volume ratio, and having undergone an abortive cytokinesis. We tested each of these to determine which, if any, cause a G1 cell cycle arrest.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-10413588, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-10477747, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-10585275, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-10723032, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-11359924, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-11781586, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-12084796, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-12537518, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-12637748, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-12682090, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-12766773, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-14616062, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-14632567, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-14744434, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-14767480, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-15184396, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-15184397, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-5409962, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-5443247, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-6243345, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-6574461, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-7568133, http://linkedlifedata.com/resource/pubmed/commentcorrection/15713235-9448003
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1471-2121
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure.
pubmed:affiliation
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA. conniewg@stanford.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural