Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-6-1
|
| pubmed:abstractText |
It has recently been demonstrated that IL-4 inhibits IL-2 receptor expression on T cells. Studies have also shown that IL-4 can inhibit IL-2-induced natural killer cell (NK) cytotoxicity, and that IL-4 in combination with IL-2 and large granular lymphocyte (NK/LGL) cells suppresses Ig synthesis. Therefore, we examine whether IL-2 receptor expression on NK/LGL cells is affected with or without IL-4, using fluorescent receptor analysis. Our results demonstrate that IL-4 inhibits/down-regulates the expression of IL-2 receptors on either phytohemagglutinin or IL-2-stimulated NK/LGL cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1015-2008
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
72-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1571094-Cell Line,
pubmed-meshheading:1571094-Cytotoxicity, Immunologic,
pubmed-meshheading:1571094-Down-Regulation,
pubmed-meshheading:1571094-Humans,
pubmed-meshheading:1571094-Interleukin-2,
pubmed-meshheading:1571094-Interleukin-4,
pubmed-meshheading:1571094-Killer Cells, Natural,
pubmed-meshheading:1571094-Lymphocyte Subsets,
pubmed-meshheading:1571094-Receptors, Interleukin-2
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Down-regulation of interleukin-2 receptor expression on natural killer cells/large granular lymphocytes by interleukin-4.
|
| pubmed:affiliation |
Biological Products Branch, Centers for Disease Control, Atlanta, Ga. 30333.
|
| pubmed:publicationType |
Journal Article
|