Source:http://linkedlifedata.com/resource/pubmed/id/15710467
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2005-2-15
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| pubmed:abstractText |
We have found previously that brain IL-2 receptors are enriched in the hippocampal formation, and that loss of this cytokine results in cytoarchitectural alterations in the hippocampus and septum and related behavioral changes in IL-2 knockout (IL-2 KO) mice. These alterations included decreased cholinergic somata in the medial septum/vertical limb of the diagonal band of Broca (MS/vDB) and decreased distance across the infrapyramidal (IP) granule cell layer (GCL) of the dentate gyrus (DG). To extend our previous findings, several experiments were conducted comparing IL-2 KO mice and wild-type littermates to determine (1) whether the GABAergic projection neurons of IL-2 KO mice in this region were also affected; (2) if the reduction in septal cholinergic projection neurons found in adult IL-2 KO mice is present at weaning (and prior to the development of peripheral autoimmune disease); and (3) if loss of IL-2 may result in changes in the neurotrophins, brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), involved in maintenance of hippocampal neurons. No differences in GABAergic neurons in the MS/vDB were found in adult mice, and the reduction in cholinergic neurons seen in adult IL-2 KO mice was not found in animals at postnatal day 21. The number of neurons in the IP-GCL was also significantly reduced. Compared to wild-type mice, IL-2 KO mice had significantly reduced concentration of BDNF protein and increased concentrations of NGF. These data suggest that the septohippocampal neuronal loss in IL-2 KO mice is selective for the cholinergic neurons and appears to be due to a failure in neuronal maintenance/survival that may be, in part, associated with changes in neurotrophins.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Choline O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Parvalbumins,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0165-5728
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
160
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
146-53
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15710467-Animals,
pubmed-meshheading:15710467-Brain Chemistry,
pubmed-meshheading:15710467-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:15710467-Cell Count,
pubmed-meshheading:15710467-Choline O-Acetyltransferase,
pubmed-meshheading:15710467-Dentate Gyrus,
pubmed-meshheading:15710467-Diagonal Band of Broca,
pubmed-meshheading:15710467-Hippocampus,
pubmed-meshheading:15710467-Interleukin-2,
pubmed-meshheading:15710467-Mice,
pubmed-meshheading:15710467-Mice, Inbred C57BL,
pubmed-meshheading:15710467-Mice, Knockout,
pubmed-meshheading:15710467-Nerve Growth Factor,
pubmed-meshheading:15710467-Neurons,
pubmed-meshheading:15710467-Parvalbumins,
pubmed-meshheading:15710467-Pyramidal Cells,
pubmed-meshheading:15710467-Septum of Brain,
pubmed-meshheading:15710467-Up-Regulation,
pubmed-meshheading:15710467-gamma-Aminobutyric Acid
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| pubmed:year |
2005
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| pubmed:articleTitle |
IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins.
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| pubmed:affiliation |
McKnight Brain Institute, L4-118, University of Florida College of Medicine, P.O. Box 100256, Gainesville, FL 32610-0256, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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