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pubmed-article:15709195pubmed:abstractTextFarnesyltransferase (FTase) inhibitors, which were designed to inhibit oncogenic Ras, act synergistically with tamoxifen in preclinical breast cancer models. We studied the safety and toxicity of tipifarnib in combination with tamoxifen in metastatic breast cancer. The pharmacokinetics and pharmacodynamics of tipifarnib were also assessed.lld:pubmed
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pubmed-article:15709195pubmed:articleTitleA phase I trial and pharmacokinetic study of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in metastatic breast cancer.lld:pubmed
pubmed-article:15709195pubmed:affiliationMedical Oncology Clinical Research Unit, National Cancer Institute/NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA. peter.lebowitz@nih.govlld:pubmed
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