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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-2-14
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pubmed:abstractText |
Farnesyltransferase (FTase) inhibitors, which were designed to inhibit oncogenic Ras, act synergistically with tamoxifen in preclinical breast cancer models. We studied the safety and toxicity of tipifarnib in combination with tamoxifen in metastatic breast cancer. The pharmacokinetics and pharmacodynamics of tipifarnib were also assessed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1247-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15709195-Adult,
pubmed-meshheading:15709195-Aged,
pubmed-meshheading:15709195-Alkyl and Aryl Transferases,
pubmed-meshheading:15709195-Anemia,
pubmed-meshheading:15709195-Antineoplastic Agents, Hormonal,
pubmed-meshheading:15709195-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15709195-Area Under Curve,
pubmed-meshheading:15709195-Breast Neoplasms,
pubmed-meshheading:15709195-Dose-Response Relationship, Drug,
pubmed-meshheading:15709195-Exanthema,
pubmed-meshheading:15709195-Farnesyltranstransferase,
pubmed-meshheading:15709195-Fatigue,
pubmed-meshheading:15709195-Female,
pubmed-meshheading:15709195-Humans,
pubmed-meshheading:15709195-Leukocytes, Mononuclear,
pubmed-meshheading:15709195-Male,
pubmed-meshheading:15709195-Middle Aged,
pubmed-meshheading:15709195-Neoplasm Metastasis,
pubmed-meshheading:15709195-Quinolones,
pubmed-meshheading:15709195-Tamoxifen,
pubmed-meshheading:15709195-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
A phase I trial and pharmacokinetic study of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in metastatic breast cancer.
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pubmed:affiliation |
Medical Oncology Clinical Research Unit, National Cancer Institute/NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA. peter.lebowitz@nih.gov
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Clinical Trial, Phase I
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