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rdf:type |
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lifeskim:mentions |
umls-concept:C0008902,
umls-concept:C0017638,
umls-concept:C0205147,
umls-concept:C0205462,
umls-concept:C0220825,
umls-concept:C0524869,
umls-concept:C0547040,
umls-concept:C1425790,
umls-concept:C1520855,
umls-concept:C1520972,
umls-concept:C1553877,
umls-concept:C1608885,
umls-concept:C1704788,
umls-concept:C1707257,
umls-concept:C1707520,
umls-concept:C1880274
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2005-2-14
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|
pubmed:abstractText |
Allelic loss at 1p is seen in 70% to 85% of oligodendrogliomas (typically in association with 19q allelic loss) and 20-30% of astrocytomas. Because most 1p deletions in gliomas involve almost the entire chromosome arm, narrowing the region of the putative tumor suppressor gene has been difficult. To better define the histologic correlates of different patterns of 1p and 19q loss, we evaluated 1p/19q status in a large group of gliomas. This also allowed us to define a very small minimal deleted region (MDR) on 1p36.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1119-28
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15709179-Adult,
pubmed-meshheading:15709179-Astrocytoma,
pubmed-meshheading:15709179-Brain Neoplasms,
pubmed-meshheading:15709179-Calcium-Binding Proteins,
pubmed-meshheading:15709179-Chromosome Deletion,
pubmed-meshheading:15709179-Chromosome Mapping,
pubmed-meshheading:15709179-Chromosomes, Human, Pair 1,
pubmed-meshheading:15709179-Chromosomes, Human, Pair 19,
pubmed-meshheading:15709179-Expressed Sequence Tags,
pubmed-meshheading:15709179-Gene Expression Profiling,
pubmed-meshheading:15709179-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15709179-Genes, Tumor Suppressor,
pubmed-meshheading:15709179-Glioma,
pubmed-meshheading:15709179-Humans,
pubmed-meshheading:15709179-Loss of Heterozygosity,
pubmed-meshheading:15709179-Microsatellite Repeats,
pubmed-meshheading:15709179-Mutation,
pubmed-meshheading:15709179-Oligodendroglioma,
pubmed-meshheading:15709179-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15709179-Trans-Activators
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pubmed:year |
2005
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pubmed:articleTitle |
Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene.
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pubmed:affiliation |
Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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