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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-2-14
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pubmed:abstractText |
To study TRPV1 immunoreactivity in the urothelium of patients with neurogenic detrusor overactivity (NDO) before and after treatment with resiniferatoxin (RTX) and controls. Functional capsaicin TRPV1 receptors have been demonstrated in urothelial cells of rodent urinary bladder, and TRPV1-knockout mice exhibit diminished nitric oxide and stretch-evoked adenosine triphosphate release from urothelial cells. In patients with NDO, TRPV1 suburothelial nerve density is increased, which is reversed by successful treatment with intravesical RTX. However, the role of urothelial TRPV1 in human bladder disorders is unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1527-9995
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
400-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15708075-Administration, Intravesical,
pubmed-meshheading:15708075-Adult,
pubmed-meshheading:15708075-Biopsy,
pubmed-meshheading:15708075-Cell Polarity,
pubmed-meshheading:15708075-Cystoscopy,
pubmed-meshheading:15708075-Diterpenes,
pubmed-meshheading:15708075-Female,
pubmed-meshheading:15708075-Humans,
pubmed-meshheading:15708075-Image Processing, Computer-Assisted,
pubmed-meshheading:15708075-Immunoenzyme Techniques,
pubmed-meshheading:15708075-Ion Channels,
pubmed-meshheading:15708075-Male,
pubmed-meshheading:15708075-Middle Aged,
pubmed-meshheading:15708075-Nerve Fibers,
pubmed-meshheading:15708075-Single-Blind Method,
pubmed-meshheading:15708075-TRPV Cation Channels,
pubmed-meshheading:15708075-Urinary Bladder,
pubmed-meshheading:15708075-Urinary Bladder, Neurogenic,
pubmed-meshheading:15708075-Urothelium
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pubmed:year |
2005
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pubmed:articleTitle |
Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin.
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pubmed:affiliation |
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
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pubmed:publicationType |
Journal Article
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