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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-2-14
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pubmed:databankReference |
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pubmed:abstractText |
Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/NR5A1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NR5A2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Steroidogenic Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/steroidogenic factor 1, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:BynumJane MJM,
pubmed-author:FletterickRobert JRJ,
pubmed-author:GuyRodney KRK,
pubmed-author:IngrahamHolly AHA,
pubmed-author:JuzumieneDaliaD,
pubmed-author:KrylovaIrina NIN,
pubmed-author:LebedevaLioudmilaL,
pubmed-author:MacKayJ AndrewJA,
pubmed-author:MadaussKevinK,
pubmed-author:MontanaValerieV,
pubmed-author:MooreJamieJ,
pubmed-author:SablinElena PEP,
pubmed-author:SuzawaMiyukiM,
pubmed-author:ThorntonJoseph WJW,
pubmed-author:WaittGregory MGM,
pubmed-author:WilliamsJon DJD,
pubmed-author:WilliamsShawn PSP,
pubmed-author:WillsonTimothy MTM,
pubmed-author:XuRobert XRX
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
343-55
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pubmed:dateRevised |
2011-9-22
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pubmed:meshHeading |
pubmed-meshheading:15707893-Animals,
pubmed-meshheading:15707893-Binding Sites,
pubmed-meshheading:15707893-Cell Line, Tumor,
pubmed-meshheading:15707893-Crystallography, X-Ray,
pubmed-meshheading:15707893-DNA-Binding Proteins,
pubmed-meshheading:15707893-Evolution, Molecular,
pubmed-meshheading:15707893-Homeodomain Proteins,
pubmed-meshheading:15707893-Humans,
pubmed-meshheading:15707893-Ligands,
pubmed-meshheading:15707893-Mice,
pubmed-meshheading:15707893-Models, Molecular,
pubmed-meshheading:15707893-Phosphatidylinositol Phosphates,
pubmed-meshheading:15707893-Phosphatidylinositols,
pubmed-meshheading:15707893-Phylogeny,
pubmed-meshheading:15707893-Protein Binding,
pubmed-meshheading:15707893-Protein Structure, Tertiary,
pubmed-meshheading:15707893-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:15707893-Signal Transduction,
pubmed-meshheading:15707893-Steroidogenic Factor 1,
pubmed-meshheading:15707893-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
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pubmed:affiliation |
Department of Physiology, University of California, San Francisco, California 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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