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rdf:type |
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lifeskim:mentions |
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0115471,
umls-concept:C0205263,
umls-concept:C0282151,
umls-concept:C0332157,
umls-concept:C0443252,
umls-concept:C0542341,
umls-concept:C0678156,
umls-concept:C0678804,
umls-concept:C1515926
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pubmed:issue |
2
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pubmed:dateCreated |
2005-2-14
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pubmed:abstractText |
We investigated several aspects of the dopaminergic and serotonergic functions throughout brain development in rats prenatally exposed to MDMA ("ecstasy"). Pregnant rats were treated with MDMA (10 mg/kg s.c.) or saline from the 13th to the 20th day of gestation and studies were conducted on the progeny from both groups: (i) quantification of whole brain contents of DA, 5-HT and metabolites from the 14th day of embryonic life (E14) to weaning (21st day of postnatal life, P21); (ii) quantification of DA and 5-HT membrane transporters by autoradiography from E18 to adult age (P70); (iii) measurement of pharmacologically induced release of DA and 5-HT using microdialysis on adult (P70) freely moving rats; (iv) measurement of sucrose preference in adults (P70). Prenatally MDMA-exposed rats showed (i) a two-fold decrease of whole brain levels of 5-HT and 5-HIAA at P0; (ii) no effect on the DAT and SERT density; (iii) a strongly reduced pharmacologically induced release of DA and 5-HT at P70 in the striatum and hippocampus; and (iv) a significant 20% decrease in sucrose preference at P70. This study suggests that a prenatal exposure to MDMA induces transient and long-term neurochemical and behavioural modifications in dopaminergic and serotonergic functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dihydroxyphenylacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Methylenedioxyamphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/3,4-methylenedioxyethamphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Fenfluramine,
http://linkedlifedata.com/resource/pubmed/chemical/Hallucinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Homovanillic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyindoleacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-(3-iodoprop-2-enyl)-2-beta-carbome...,
http://linkedlifedata.com/resource/pubmed/chemical/Nortropanes,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Tyramine
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0165-3806
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-76
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15707670-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:15707670-3,4-Methylenedioxyamphetamine,
pubmed-meshheading:15707670-Adrenergic Uptake Inhibitors,
pubmed-meshheading:15707670-Age Factors,
pubmed-meshheading:15707670-Analysis of Variance,
pubmed-meshheading:15707670-Animals,
pubmed-meshheading:15707670-Animals, Newborn,
pubmed-meshheading:15707670-Autoradiography,
pubmed-meshheading:15707670-Brain,
pubmed-meshheading:15707670-Brain Chemistry,
pubmed-meshheading:15707670-Dopamine,
pubmed-meshheading:15707670-Embryo, Mammalian,
pubmed-meshheading:15707670-Female,
pubmed-meshheading:15707670-Fenfluramine,
pubmed-meshheading:15707670-Hallucinogens,
pubmed-meshheading:15707670-Homovanillic Acid,
pubmed-meshheading:15707670-Hydroxyindoleacetic Acid,
pubmed-meshheading:15707670-Male,
pubmed-meshheading:15707670-Membrane Transport Proteins,
pubmed-meshheading:15707670-Microdialysis,
pubmed-meshheading:15707670-Nortropanes,
pubmed-meshheading:15707670-Pregnancy,
pubmed-meshheading:15707670-Prenatal Exposure Delayed Effects,
pubmed-meshheading:15707670-Rats,
pubmed-meshheading:15707670-Rats, Wistar,
pubmed-meshheading:15707670-Serotonin,
pubmed-meshheading:15707670-Serotonin Uptake Inhibitors,
pubmed-meshheading:15707670-Sex Factors,
pubmed-meshheading:15707670-Time Factors,
pubmed-meshheading:15707670-Tyramine
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pubmed:year |
2005
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pubmed:articleTitle |
Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat.
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pubmed:affiliation |
INSERM U619, IFR135, Laboratoire de Biophysique Médicale and Pharmaceutique, Université François Rabelais des Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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