Linked Life Data

1570615

Source:http://linkedlifedata.com/resource/pubmed/id/1570615

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-5-28
pubmed:abstractText
A hemoglobin based "blood substitute" developed at Texas Tech University and produced in Italy was used in nine children with sickle cell anemia admitted to the Centre de l'Anemie S. S. of Kinshasa, Zaire. Five of the children presented an "aplastic crisis," for example, a sudden decrease in hemoglobin concentration associated with absence of reticulocytes in the peripheral blood, and four were admitted with unremitting severe pain because of a "vaso-occlusive crisis." The blood substitute contained 10 per cent hemoglobin and was infused in a volume corresponding to 25 per cent of blood volume (calculated for each child as equal to 7 per cent of body weight in kilograms). No adverse reaction was noted. To the contrary, all patients presented beneficial effects. In the patients with aplastic crisis, the hemoglobin solution stimulated the bone marrow to a significant erythropoietic effect, whereby the number of reticulocytes in the peripheral blood increased from zero to 47 +/- 7 per cent. In the patients with vaso-occlusive crises, pain was quickly relieved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0039-6087
pubmed:author
pubmed:issnType
Print
pubmed:volume
174
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
379-86
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Clinical trial of a hemoglobin based blood substitute in patients with sickle cell anemia.
pubmed:affiliation
Department of Surgery, Texas Tech University Health Sciences Center, Lubbock 79430.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study