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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-5-20
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pubmed:abstractText |
Homing of mast cell progenitors (MCps) to the mouse small intestine involves the interaction of alpha4beta7 integrin with mucosal addressin cellular adhesion molecule-1 (MAdCAM-1). We now demonstrate the dependence of this process on CXC chemokine receptor 2 (CXCR2) and vascular cell adhesion molecule-1 (VCAM-1) using null strains and mice sublethally irradiated and bone marrow (BM) reconstituted (SIBR) with wild-type or null BM or with wild-type BM followed by administration of blocking antibody. The intestinal MCp concentration in CXCR2(-/-) mice was reduced by 67%, but was unaltered in CC chemokine receptor 2(-/-) (CCR2(-/-)), CCR3(-/-), or CCR5(-/-) mice. SIBR mice given CXCR2(-/-) BM had an intestinal MCp concentration that was 76% less than that in BALB/c BM reconstituted mice. Antibody blockade of VCAM-1 or of CXCR2 in SIBR mice reduced intestinal MCp reconstitution, and mice lacking endothelial VCAM-1 also had a marked reduction relative to wild-type mice. Finally, the half-life of intestinal MCps in wild-type mice was less than one week on the basis of a more than 50% reduction by administration of anti-alpha4beta7 integrin or anti-CXCR2. Thus, the establishment and maintenance of MCps in the small intestine is a dynamic process that requires expression of the alpha4beta7 integrin and the alpha-chemokine receptor CXCR2.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-10216072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-10432289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-10484382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-10898502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11018170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11023662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11257140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11306951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11339505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11342480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11444905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11696590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11785982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11830666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-11850627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-12439624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-12468547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-12560232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-12618265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-2917992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-3084797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-4162018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-6429265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-6863935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-7523506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-7539357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-7622488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-7636264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-7648391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-8036519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-8103045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-8288247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-8496601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-8502297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-8858180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-8920870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-9342361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-9463410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15705791-9605168
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4308-13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15705791-Animals,
pubmed-meshheading:15705791-Cell Count,
pubmed-meshheading:15705791-Cell Movement,
pubmed-meshheading:15705791-Integrins,
pubmed-meshheading:15705791-Intestines,
pubmed-meshheading:15705791-Male,
pubmed-meshheading:15705791-Mast Cells,
pubmed-meshheading:15705791-Mice,
pubmed-meshheading:15705791-Mice, Inbred BALB C,
pubmed-meshheading:15705791-Mice, Knockout,
pubmed-meshheading:15705791-RNA, Messenger,
pubmed-meshheading:15705791-Receptors, Interleukin-8B,
pubmed-meshheading:15705791-Stem Cells,
pubmed-meshheading:15705791-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2005
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pubmed:articleTitle |
Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.
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pubmed:affiliation |
Department of Pediatrics, Cincinnati Children's Medical Center, OH, USA.
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