Linked Life Data

15704347

Source:http://linkedlifedata.com/resource/pubmed/id/15704347

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-2-11
pubmed:abstractText
Excitatory neurotransmitters, the most important of which is glutamate, increase the activity of signal. receiving neurons and play a major role in controlling brain function. Glutamate exerts its effects on cells in part through three types of receptors that, when activated, allow the flow of positively charged ions into the cell. Of these, the N-methyl-D-aspartate (NMDA) receptor plays a particularly important role in controlling the brain's ability to adapt to environmental and genetic influences. Even low alcohol concentrations can inhibit the excitatory activity of the NMDA receptor. This inhibition of NMDA receptor function may be one of the mechanisms contributing to fetal alcohol syndrome and other more subtle developmental abnormalities. Moreover, alcohol-induced impairment of the NMDA receptor may contribute to alcohol-related learning disabilities, neuronal losses, and cognitive deficits as well as to some of the manifestations of alcohol withdrawal.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0090-838X
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Alcohol and glutamate.
pubmed:affiliation
Department of Pharmacology, College of Pharmacy, University of Texas, Austin, Texas, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review