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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-5-27
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pubmed:abstractText |
The effects of nimodipine and thyrotropin-releasing hormone (TRH) were compared in a clip-compression model of experimental spinal cord injuries (SCI) in rats. Thirty rats received a 50-g clip-compression injury on the cord at T9. Ten rats were given 0.02 mg/kg nimodipine and dextran 40 (3 ml) i.v. 1 h after injury. Ten rats were given 2 mg/kg TRH and dextran 40 (3 ml) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. The remaining ten rats were given only saline. TRH treatment significantly improved somatosensory-evoked potentials (SEPs) and mean arterial blood pressures (MABPs), whereas nimodipine treatment had no effect on these variables (Fisher's exact test (P less than 0.01).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-9130
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
192
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1570411-Animals,
pubmed-meshheading:1570411-Blood Pressure,
pubmed-meshheading:1570411-Calcium,
pubmed-meshheading:1570411-Disease Models, Animal,
pubmed-meshheading:1570411-Evoked Potentials, Somatosensory,
pubmed-meshheading:1570411-Heart Rate,
pubmed-meshheading:1570411-Nimodipine,
pubmed-meshheading:1570411-Rats,
pubmed-meshheading:1570411-Rats, Inbred Strains,
pubmed-meshheading:1570411-Spinal Cord Injuries,
pubmed-meshheading:1570411-Thyrotropin-Releasing Hormone
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pubmed:year |
1992
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pubmed:articleTitle |
Treatment of acute spinal cord injuries: comparison of thyrotropin-releasing hormone and nimodipine.
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pubmed:affiliation |
Department of Neurosurgery, KTU Medical Faculty, Trabzon, Turkey.
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pubmed:publicationType |
Journal Article,
Comparative Study
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