Linked Life Data

15703814

Source:http://linkedlifedata.com/resource/pubmed/id/15703814

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-2-10
pubmed:abstractText
The Y-box binding protein 1 (YB-1) regulates gene expression through transcription and translation. YB-1 has been shown to be associated with up-regulation of P-glycoprotein (Pgp), an ATP-binding transporter involved in multi-drug resistance. In this study, we determined the prognostic significance of YB-1 and its relationship with Pgp in patients with breast cancer. YB-1 and Pgp expression were evaluated by immunohistochemistry in resected specimens of infiltrative ductal breast cancers from 99 patients and 57 patients respectively and correlated with clinicopathological parameters and adjuvant chemotherapy regimes. The antibody for the YB-1 protein was prepared by injecting a rabbit with a purified recombinant chicken YB1 protein. The relationship between YB-1 and Pgp was also evaluated by a computational approach using the Resonant Recognition Model (RRM). We found that breast tumors which were both estrogen receptor-negative and lymph node positive were associated with high YB-1 expression (P=0.017). In patients who did not receive adjuvant chemotherapy, recurrence risk was reduced in breast cancers having lower YB-1 expression (P=0.034), suggesting that high levels of YB-1 expression in breast cancer is associated with tumor aggressiveness. We were able to demonstrate a direct interaction between YB-1 and Pgp using the computer-based RRM. Interestingly, we found that patients who were on a chemotherapy regime which contained an anthracycline (a Pgp substrate) and subsequently developed recurrence, had a higher YB-1 score compared to patients on the Cyclophosphamide/Methotrexate/5-Fluorouracil regime (P=0.024). YB-1 expression in breast cancer may be a potential marker of chemoresistance and could possibly aid in selection of the appropriate adjuvant chemotherapy regime for breast cancers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1019-6439
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
607-13
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15703814-Adult, pubmed-meshheading:15703814-Aged, pubmed-meshheading:15703814-Aged, 80 and over, pubmed-meshheading:15703814-Breast Neoplasms, pubmed-meshheading:15703814-Carcinoma, Ductal, Breast, pubmed-meshheading:15703814-Chemotherapy, Adjuvant, pubmed-meshheading:15703814-DNA-Binding Proteins, pubmed-meshheading:15703814-Disease Progression, pubmed-meshheading:15703814-Drug Resistance, Neoplasm, pubmed-meshheading:15703814-Female, pubmed-meshheading:15703814-Humans, pubmed-meshheading:15703814-Immunohistochemistry, pubmed-meshheading:15703814-Middle Aged, pubmed-meshheading:15703814-Nuclear Proteins, pubmed-meshheading:15703814-P-Glycoprotein, pubmed-meshheading:15703814-Prognosis, pubmed-meshheading:15703814-Receptors, Estrogen, pubmed-meshheading:15703814-Treatment Outcome, pubmed-meshheading:15703814-Tumor Markers, Biological, pubmed-meshheading:15703814-Up-Regulation, pubmed-meshheading:15703814-Y-Box-Binding Protein 1
pubmed:year
2005
pubmed:articleTitle
Y-box binding protein, YB-1, as a marker of tumor aggressiveness and response to adjuvant chemotherapy in breast cancer.
pubmed:affiliation
Department of Anatomy, Faculty of Medicine, National University of Singapore, Singapore.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't