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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1992-5-28
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pubmed:abstractText |
Minihelices mimicking the amino acid acceptor and anticodon branches of yeast tRNA(Val) have been synthesized by in vitro transcription of synthetic templates. It is shown that a minihelix corresponding to the amino acid acceptor branch and containing solely a valine-specific identity nucleotide can be aminoacylated by yeast valyl-tRNA synthetase. Its charging ability is lost after mutating this nucleotide. This ability is stimulated somewhat by the addition of a second hairpin helix that mimicks the anticodon arm, which suggests that information originating from the anticodon stem-loop can be transmitted to the active site of the enzyme by the core of the protein.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-1704363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-1729719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-1809333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-1856854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-1857423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-1882076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-1991471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2047878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2068095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2203971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2236077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2251270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2330033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2452483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2459397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2459773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2470031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2482421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2646717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2663057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2663062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2678006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-2915692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-3055296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-3086742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-3285220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-348466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-3684574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-3911276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-409999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-4150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-4567121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-5271039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-7015339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570324-795646
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3990-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1570324-Anticodon,
pubmed-meshheading:1570324-Base Sequence,
pubmed-meshheading:1570324-Hydrogen Bonding,
pubmed-meshheading:1570324-Molecular Sequence Data,
pubmed-meshheading:1570324-RNA, Transfer, Val,
pubmed-meshheading:1570324-Saccharomyces cerevisiae,
pubmed-meshheading:1570324-Structure-Activity Relationship,
pubmed-meshheading:1570324-Transfer RNA Aminoacylation,
pubmed-meshheading:1570324-Valine-tRNA Ligase
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pubmed:year |
1992
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pubmed:articleTitle |
Anticodon-independent aminoacylation of an RNA minihelix with valine.
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pubmed:affiliation |
Laboratoire de Biochimie, Centre National de la Recherche Scientifique, Strasbourg, France.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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