| pubmed-article:1570303 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C1519697 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1570303 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1570303 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1570303 | pubmed:dateCreated | 1992-5-28 | lld:pubmed |
| pubmed-article:1570303 | pubmed:abstractText | We have examined the immunoregulatory effect of local and continuous secretion of interleukin 7 (IL-7) from murine glioma cells (203-glioma) engineered by murine IL-7 gene transfection. Secretion of IL-7 from glioma cells did not result in morphology or growth rate changes but did reduce tumorigenicity in vivo in proportion to the amount of IL-7 produced. This reduction in tumorigenicity could be reversed in a dose-dependent fashion by injection of anti-IL-7 neutralizing monoclonal antibody at the tumor site. Mice immunized with IL-7-producing glioma cells showed a specific immune response to 203-glioma but not to two other syngeneic cell lines (B-16, a melanoma, and YM-12, a fibrosarcoma). IL-7-producing glioma cells were not rejected in mice depleted of CD8+ cells but were rejected in mice depleted of CD4+ or NK1.1+ cells. These results suggest that CD8+ T cells may play an important role in tumor rejection. | lld:pubmed |
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| pubmed-article:1570303 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1570303 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1570303 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1570303 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1570303 | pubmed:month | May | lld:pubmed |
| pubmed-article:1570303 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1570303 | pubmed:author | pubmed-author:NakanoTT | lld:pubmed |
| pubmed-article:1570303 | pubmed:author | pubmed-author:KikuchiHH | lld:pubmed |
| pubmed-article:1570303 | pubmed:author | pubmed-author:AokiTT | lld:pubmed |
| pubmed-article:1570303 | pubmed:author | pubmed-author:HonjoTT | lld:pubmed |
| pubmed-article:1570303 | pubmed:author | pubmed-author:TashiroKK | lld:pubmed |
| pubmed-article:1570303 | pubmed:author | pubmed-author:OdaYY | lld:pubmed |
| pubmed-article:1570303 | pubmed:author | pubmed-author:MiyatakeSS | lld:pubmed |
| pubmed-article:1570303 | pubmed:author | pubmed-author:KinashiTT | lld:pubmed |
| pubmed-article:1570303 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1570303 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1570303 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1570303 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1570303 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1570303 | pubmed:pagination | 3850-4 | lld:pubmed |
| pubmed-article:1570303 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1570303 | pubmed:meshHeading | pubmed-meshheading:1570303-... | lld:pubmed |
| pubmed-article:1570303 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1570303 | pubmed:articleTitle | Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo. | lld:pubmed |
