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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0017638,
umls-concept:C0021761,
umls-concept:C0185117,
umls-concept:C0392756,
umls-concept:C0591833,
umls-concept:C1274040,
umls-concept:C1515655,
umls-concept:C1519697,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
1992-5-28
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pubmed:abstractText |
We have examined the immunoregulatory effect of local and continuous secretion of interleukin 7 (IL-7) from murine glioma cells (203-glioma) engineered by murine IL-7 gene transfection. Secretion of IL-7 from glioma cells did not result in morphology or growth rate changes but did reduce tumorigenicity in vivo in proportion to the amount of IL-7 produced. This reduction in tumorigenicity could be reversed in a dose-dependent fashion by injection of anti-IL-7 neutralizing monoclonal antibody at the tumor site. Mice immunized with IL-7-producing glioma cells showed a specific immune response to 203-glioma but not to two other syngeneic cell lines (B-16, a melanoma, and YM-12, a fibrosarcoma). IL-7-producing glioma cells were not rejected in mice depleted of CD8+ cells but were rejected in mice depleted of CD4+ or NK1.1+ cells. These results suggest that CD8+ T cells may play an important role in tumor rejection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-1683534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-1706752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-1712810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-1832488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-1975262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2007858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2016545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2022919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2112086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2137372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2142722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2162905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2208133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2212951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2512580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2555412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2643102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2785856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2787384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2787831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2788279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2831066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-2955227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3119325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3258354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3259157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3259677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3289570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3322813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3351434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3484674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3528289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3528866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-360795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3782794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3878229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-3934273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-6246361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-6333639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-6438633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-6607949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-6801178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-730383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1570303-89034
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3850-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1570303-Animals,
pubmed-meshheading:1570303-Antigens, CD8,
pubmed-meshheading:1570303-Glioma,
pubmed-meshheading:1570303-Graft Rejection,
pubmed-meshheading:1570303-Immunity, Cellular,
pubmed-meshheading:1570303-Interleukin-7,
pubmed-meshheading:1570303-Killer Cells, Natural,
pubmed-meshheading:1570303-Mice,
pubmed-meshheading:1570303-Mice, Inbred C57BL,
pubmed-meshheading:1570303-Neoplasm Transplantation,
pubmed-meshheading:1570303-Neoplasms, Experimental,
pubmed-meshheading:1570303-Recombinant Proteins,
pubmed-meshheading:1570303-T-Lymphocyte Subsets,
pubmed-meshheading:1570303-Transfection,
pubmed-meshheading:1570303-Tumor Cells, Cultured
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pubmed:year |
1992
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pubmed:articleTitle |
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.
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