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rdf:type |
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lifeskim:mentions |
umls-concept:C0017725,
umls-concept:C0021641,
umls-concept:C0028754,
umls-concept:C0034693,
umls-concept:C0037083,
umls-concept:C0037663,
umls-concept:C0087111,
umls-concept:C0301630,
umls-concept:C0439590,
umls-concept:C0580836,
umls-concept:C1280500,
umls-concept:C1563743,
umls-concept:C1710082,
umls-concept:C1832073
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pubmed:issue |
1
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pubmed:dateCreated |
2005-2-9
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pubmed:abstractText |
Growth Hormone (GH) promotes loss of body fat and causes insulin resistance. It is debated whether reduction of body fat mass during long term growth hormone (GH) administration improves carbohydrate metabolism. To answer this question we assessed carbohydrate handling and tissue specific function of the insulin receptor (IR) and insulin receptor substrate-1 (IRS-1) during prolonged GH treatment of obese rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/IRS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1096-6374
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-63
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15701573-Adipose Tissue,
pubmed-meshheading:15701573-Aging,
pubmed-meshheading:15701573-Animals,
pubmed-meshheading:15701573-Area Under Curve,
pubmed-meshheading:15701573-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15701573-Female,
pubmed-meshheading:15701573-Glucose,
pubmed-meshheading:15701573-Growth Hormone,
pubmed-meshheading:15701573-Humans,
pubmed-meshheading:15701573-Immunoprecipitation,
pubmed-meshheading:15701573-Insulin,
pubmed-meshheading:15701573-Insulin Receptor Substrate Proteins,
pubmed-meshheading:15701573-Insulin Resistance,
pubmed-meshheading:15701573-Janus Kinase 2,
pubmed-meshheading:15701573-Lipid Metabolism,
pubmed-meshheading:15701573-Liver,
pubmed-meshheading:15701573-Muscles,
pubmed-meshheading:15701573-Obesity,
pubmed-meshheading:15701573-Phosphoproteins,
pubmed-meshheading:15701573-Phosphorylation,
pubmed-meshheading:15701573-Protein-Tyrosine Kinases,
pubmed-meshheading:15701573-Proto-Oncogene Proteins,
pubmed-meshheading:15701573-RNA,
pubmed-meshheading:15701573-Rats,
pubmed-meshheading:15701573-Rats, Wistar,
pubmed-meshheading:15701573-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15701573-Signal Transduction,
pubmed-meshheading:15701573-Time Factors,
pubmed-meshheading:15701573-Tyrosine
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pubmed:year |
2005
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pubmed:articleTitle |
Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling.
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pubmed:affiliation |
Department of Pharmacological Research, Discovery, Novo Nordisk, DK-2760 Måløv, Denmark. thuj@novonordisk.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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