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rdf:type |
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lifeskim:mentions |
umls-concept:C0016360,
umls-concept:C0030705,
umls-concept:C0077681,
umls-concept:C0205179,
umls-concept:C0205195,
umls-concept:C0280100,
umls-concept:C0919418,
umls-concept:C0920321,
umls-concept:C1152568,
umls-concept:C1332739,
umls-concept:C1511576,
umls-concept:C1514555
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pubmed:issue |
9
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pubmed:dateCreated |
2005-3-18
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pubmed:abstractText |
Preclinical studies indicate that the cyclin-dependent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN-01) potentiates the cytotoxic effects of fluorouracil (FU). We designed a phase I clinical trial of FU in combination with UCN-01.
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pubmed:grant |
|
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:GonenMithatM,
pubmed-author:IlsonDavid IDI,
pubmed-author:KaubischAndreasA,
pubmed-author:KelsenDavid PDP,
pubmed-author:KemenyNancyN,
pubmed-author:KortmanskyJeremyJ,
pubmed-author:MakiRobert GRG,
pubmed-author:O'reillyEileenE,
pubmed-author:SaltzLeonard BLB,
pubmed-author:SchwartzGary KGK,
pubmed-author:ShahManish AMA,
pubmed-author:SowersRebeccaR,
pubmed-author:TongWilliamW,
pubmed-author:WeyerbacherAmandaA,
pubmed-author:YiSandyS
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
23
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1875-84
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15699481-Adult,
pubmed-meshheading:15699481-Aged,
pubmed-meshheading:15699481-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15699481-Area Under Curve,
pubmed-meshheading:15699481-Female,
pubmed-meshheading:15699481-Fluorouracil,
pubmed-meshheading:15699481-Half-Life,
pubmed-meshheading:15699481-Humans,
pubmed-meshheading:15699481-Infusions, Intravenous,
pubmed-meshheading:15699481-Male,
pubmed-meshheading:15699481-Middle Aged,
pubmed-meshheading:15699481-Neoplasms,
pubmed-meshheading:15699481-Protein Kinase Inhibitors,
pubmed-meshheading:15699481-Staurosporine,
pubmed-meshheading:15699481-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
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pubmed:affiliation |
Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA. schwartg@mskcc.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Clinical Trial, Phase I
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