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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0023688,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0086597,
umls-concept:C0231180,
umls-concept:C0425152,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1425775,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
4
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pubmed:dateCreated |
2005-2-8
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pubmed:abstractText |
CD8+ T cells require a signal through a costimulatory receptor in addition to TCR engagement to become activated. The role of CD28 in costimulating T cell activation is well established. NKG2D, a receptor found on NK cells, CD8+ alphabeta-TCR+ T cells, and gammadelta-TCR+ T cells, has also been implicated in T cell costimulation. In this study we have evaluated the role of NKG2D in costimulating mouse and human naive and effector CD8+ T cells. Unexpectedly, in contrast to CD28, NKG2D engagement by ligand or mAb is not sufficient to costimulate naive or effector CD8+ T cell responses in conventional T cell populations. While NKG2D did not costimulate CD8+ T cells on its own, it was able to modify CD28-mediated costimulation of human CD8+ T cells under certain contitions. It is, therefore, likely that NKG2D acts as a costimulatory molecule only under restricted conditions or requires additional cofactors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/KLRK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Klrk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1922-31
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15699119-Adjuvants, Immunologic,
pubmed-meshheading:15699119-Animals,
pubmed-meshheading:15699119-Antibodies, Monoclonal,
pubmed-meshheading:15699119-Antigens, CD28,
pubmed-meshheading:15699119-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15699119-Cell Line, Tumor,
pubmed-meshheading:15699119-Cells, Cultured,
pubmed-meshheading:15699119-Coculture Techniques,
pubmed-meshheading:15699119-Cross-Linking Reagents,
pubmed-meshheading:15699119-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:15699119-G0 Phase,
pubmed-meshheading:15699119-Humans,
pubmed-meshheading:15699119-Interferon-gamma,
pubmed-meshheading:15699119-Ligands,
pubmed-meshheading:15699119-Lymphocyte Activation,
pubmed-meshheading:15699119-Melanoma, Experimental,
pubmed-meshheading:15699119-Mice,
pubmed-meshheading:15699119-Mice, Inbred C57BL,
pubmed-meshheading:15699119-Mice, Inbred DBA,
pubmed-meshheading:15699119-Mice, Transgenic,
pubmed-meshheading:15699119-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:15699119-Receptors, Antigen, T-Cell,
pubmed-meshheading:15699119-Receptors, Immunologic,
pubmed-meshheading:15699119-Receptors, Natural Killer Cell
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pubmed:year |
2005
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pubmed:articleTitle |
Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.
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pubmed:affiliation |
Department of Microbiology and Immunology and The Cancer Research Institute, University of California, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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