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pubmed-article:15698596pubmed:abstractTextTetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthase, and GTP cyclohydrolase I (GCHI) is a rate-limiting enzyme in the biosynthesis of BH4. The expression of inducible nitric oxide synthase (iNOS) was earlier demonstrated in the ventricles of patients with dilated cardiomyopathy (DCM) although that of GCHI was not clarified. The present study was designed to determine the GCHI mRNA expression as well as to confirm iNOS mRNA expression in endomyocardial biopsy specimens from patients with DCM.lld:pubmed
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pubmed-article:15698596pubmed:dateRevised2011-10-27lld:pubmed
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pubmed-article:15698596pubmed:year2005lld:pubmed
pubmed-article:15698596pubmed:articleTitleSuppressed expression of GTP cyclohydrolase I mRNA and accelerated expression of inducible nitric oxide synthase mRNA in endomyocardial biopsy specimens from patients with dilated cardiomyopathy.lld:pubmed
pubmed-article:15698596pubmed:affiliationDepartment of Internal Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. mohtsuki@fujita-hu.ac.jplld:pubmed
pubmed-article:15698596pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15698596pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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