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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-2-8
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pubmed:abstractText |
Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthase, and GTP cyclohydrolase I (GCHI) is a rate-limiting enzyme in the biosynthesis of BH4. The expression of inducible nitric oxide synthase (iNOS) was earlier demonstrated in the ventricles of patients with dilated cardiomyopathy (DCM) although that of GCHI was not clarified. The present study was designed to determine the GCHI mRNA expression as well as to confirm iNOS mRNA expression in endomyocardial biopsy specimens from patients with DCM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-8981
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pubmed:author |
pubmed-author:HiramitsuShinyaS,
pubmed-author:HishidaHitoshiH,
pubmed-author:KatoShigeruS,
pubmed-author:KatoYasuchikaY,
pubmed-author:MorimotoShin-ichiroS,
pubmed-author:NomuraTakahideT,
pubmed-author:OhtsukiMasatsuguM,
pubmed-author:ShimokuboJunkoJ,
pubmed-author:ShiraishiHiroakiH,
pubmed-author:UemuraAkihisaA,
pubmed-author:YamamotoNaokiN
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pubmed:issnType |
Print
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pubmed:volume |
353
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-7
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:15698596-Base Sequence,
pubmed-meshheading:15698596-Biopsy,
pubmed-meshheading:15698596-Cardiomyopathy, Dilated,
pubmed-meshheading:15698596-Case-Control Studies,
pubmed-meshheading:15698596-DNA Primers,
pubmed-meshheading:15698596-GTP Cyclohydrolase,
pubmed-meshheading:15698596-Humans,
pubmed-meshheading:15698596-Myocardium,
pubmed-meshheading:15698596-Nitric Oxide Synthase,
pubmed-meshheading:15698596-Nitric Oxide Synthase Type II,
pubmed-meshheading:15698596-RNA, Messenger,
pubmed-meshheading:15698596-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2005
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pubmed:articleTitle |
Suppressed expression of GTP cyclohydrolase I mRNA and accelerated expression of inducible nitric oxide synthase mRNA in endomyocardial biopsy specimens from patients with dilated cardiomyopathy.
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pubmed:affiliation |
Department of Internal Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. mohtsuki@fujita-hu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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