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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-2-25
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pubmed:databankReference |
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pubmed:abstractText |
Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding protein MeCP2. Here we show that human Brahma (Brm), a catalytic component of the SWI/SNF-related chromatin-remodeling complex, associates with MeCP2 in vivo and is functionally linked with repression. We used a number of different molecular approaches and chromatin immunoprecipitation strategies to show a unique cooperation between Brm, BAF57 and MeCP2. We show that Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome. These experimental findings identify a new role for SWI/SNF in gene repression by MeCP2.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FMR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fmr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fragile X Mental Retardation Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/MECP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mecp2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl-CpG-Binding Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SWI-SNF-B chromatin-remodeling...,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/brm protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:BakerEmma KEK,
pubmed-author:BassalSaharS,
pubmed-author:BrasacchioDaniellaD,
pubmed-author:ChowMaggie ZMZ,
pubmed-author:CraigJeff MJM,
pubmed-author:El-OstaAssamA,
pubmed-author:HarikrishnanK NKN,
pubmed-author:JonesPeter LPL,
pubmed-author:PalSharmisthaS,
pubmed-author:SifSaïdS,
pubmed-author:WangLiL
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
254-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15696166-Animals,
pubmed-meshheading:15696166-Cell Cycle Proteins,
pubmed-meshheading:15696166-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:15696166-DNA-Binding Proteins,
pubmed-meshheading:15696166-Drosophila Proteins,
pubmed-meshheading:15696166-Fragile X Mental Retardation Protein,
pubmed-meshheading:15696166-Gene Silencing,
pubmed-meshheading:15696166-Histones,
pubmed-meshheading:15696166-Humans,
pubmed-meshheading:15696166-Methyl-CpG-Binding Protein 2,
pubmed-meshheading:15696166-Mice,
pubmed-meshheading:15696166-Microscopy, Fluorescence,
pubmed-meshheading:15696166-Molecular Sequence Data,
pubmed-meshheading:15696166-NIH 3T3 Cells,
pubmed-meshheading:15696166-Nerve Tissue Proteins,
pubmed-meshheading:15696166-RNA-Binding Proteins,
pubmed-meshheading:15696166-Repressor Proteins,
pubmed-meshheading:15696166-Trans-Activators,
pubmed-meshheading:15696166-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.
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pubmed:affiliation |
The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor, Commercial Road, Prahran, Victoria 3181, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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