Linked Life Data

15696090

Source:http://linkedlifedata.com/resource/pubmed/id/15696090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-2-7
pubmed:abstractText
Understanding the pathophysiology and basic mechanisms of asthma and chronic obstructive pulmonary disease (COPD) has been an intense source of investigation over the years. For decades, research in these fields has focused on the control of inflammation. However, new evidence has emerged demonstrating that airway inflammation is just the surface of a more complex pathobiological relationship between the disease and its host. Specifically, the relationship is a unique interaction of one's genetic background and the environment. The airway response to inhaled endotoxin serves as an effective model for studying the pathobiology of asthma as well as the importance of host genetic susceptibility. In this review, we provide a brief overview on the role of endotoxin in asthma and COPD, highlighting a few of the major discoveries, but also discussing future directions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0091-6749
pubmed:author
pubmed:issnType
Print
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
330-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Endotoxin and the lung: Insight into the host-environment interaction.
pubmed:affiliation
Duke University Medical Center, Durham, NC 27710, USA. Jaspal.Singh@duke.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.