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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2005-2-7
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|
pubmed:abstractText |
Targeted inhibition of protein kinases with small molecule drugs has evolved into a viable approach for anticancer therapy. However, the true selectivity of these therapeutic agents has remained unclear. Here, we used a proteomic method to profile the cellular targets of the clinical epidermal growth factor receptor kinase inhibitor gefitinib. Our data suggest alternative cellular modes of action for gefitinib and provide rationales for the development of related drugs.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0008-5472
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|
pubmed:author |
pubmed-author:BlenckeStephanieS,
pubmed-author:BrehmerDirkD,
pubmed-author:CottenMattM,
pubmed-author:DaubHenrikH,
pubmed-author:GodlKlausK,
pubmed-author:GreffZoltánZ,
pubmed-author:KériGyörgyG,
pubmed-author:KleblBertB,
pubmed-author:KurtenbachAlexanderA,
pubmed-author:MüllerStefanS,
pubmed-author:WeberMartinaM,
pubmed-author:WissingJosefJ
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|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
379-82
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|
pubmed:dateRevised |
2009-11-19
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|
pubmed:meshHeading |
pubmed-meshheading:15695376-Animals,
pubmed-meshheading:15695376-Antineoplastic Agents,
pubmed-meshheading:15695376-COS Cells,
pubmed-meshheading:15695376-Cercopithecus aethiops,
pubmed-meshheading:15695376-HeLa Cells,
pubmed-meshheading:15695376-Humans,
pubmed-meshheading:15695376-Protein Kinase Inhibitors,
pubmed-meshheading:15695376-Proteomics,
pubmed-meshheading:15695376-Quinazolines,
pubmed-meshheading:15695376-Receptor, Epidermal Growth Factor,
pubmed-meshheading:15695376-Structure-Activity Relationship
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Cellular targets of gefitinib.
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|
pubmed:affiliation |
Axxima Pharmaceuticals AG, Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
