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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-5-9
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pubmed:abstractText |
The majority of Candida albicans strains in nature are a/alpha and must undergo homozygosis to a/a or alpha/alpha to mate. Here we have used a mouse model for systemic infection to test the hypothesis that a/alpha strains predominate in nature because they have a competitive advantage over a/a and alpha/alpha offspring in colonizing hosts. Single-strain injection experiments revealed that a/alpha strains were far more virulent than either their a/a or alpha/alpha offspring. When equal numbers of parent a/alpha and offspring a/a or alpha/alpha cells were co-injected, a/alpha always exhibited a competitive advantage at the time of extreme host morbidity or death. When equal numbers of an engineered a/a/alpha2 strain and its isogenic a/a parent strain were co-injected, the a/a/alpha2 strain exhibited a competitive advantage at the time of host morbidity or death, suggesting that the genotype of the mating-type (MTL) locus, not associated genes on chromosome 5, provides a competitive advantage. We therefore propose that heterozygosity at the MTL locus not only represses white-opaque switching and genes involved in the mating process, but also affects virulence, providing a competitive advantage to the a/alpha genotype that conserves the mating system of C. albicans in nature.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-10455055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-10564518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-10894780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-10894781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-11119495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-11880401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-12149321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-12176317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-12399384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-12582122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-12654648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-14555467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-14556989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-14693548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-14696036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-15035040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-15654090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-2692852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-3316187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-3539914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-387610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-397913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-7868597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-808868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-8415722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-8901606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-9353021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-9919698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15695357-9928492
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1883-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15695357-Animals,
pubmed-meshheading:15695357-Antigens, Fungal,
pubmed-meshheading:15695357-Binding, Competitive,
pubmed-meshheading:15695357-Candida albicans,
pubmed-meshheading:15695357-Disease Models, Animal,
pubmed-meshheading:15695357-Fungal Proteins,
pubmed-meshheading:15695357-Gene Expression Regulation, Fungal,
pubmed-meshheading:15695357-Genes, Fungal,
pubmed-meshheading:15695357-Genes, Mating Type, Fungal,
pubmed-meshheading:15695357-Genetic Engineering,
pubmed-meshheading:15695357-Genotype,
pubmed-meshheading:15695357-Heterozygote,
pubmed-meshheading:15695357-Mice,
pubmed-meshheading:15695357-Models, Genetic,
pubmed-meshheading:15695357-Phenotype,
pubmed-meshheading:15695357-Polymerase Chain Reaction,
pubmed-meshheading:15695357-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15695357-Time Factors,
pubmed-meshheading:15695357-Virulence
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pubmed:year |
2005
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pubmed:articleTitle |
Increased virulence and competitive advantage of a/alpha over a/a or alpha/alpha offspring conserves the mating system of Candida albicans.
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pubmed:affiliation |
Department of Biological Sciences, The University of Iowa, Iowa City, 52242-1324, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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