Linked Life Data

15694941

Source:http://linkedlifedata.com/resource/pubmed/id/15694941

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-2-7
pubmed:abstractText
A series of epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation. Therefore, we examined the cross-sectional association between deciles of serum GGT and concentrations of serum C-reactive protein (CRP), a marker of chronic inflammation, among 12,110 adult participants in the third U.S. National Health and Nutrition Examination Survey. After adjustment for race, sex, age, cigarette smoking, alcohol intake, and body mass index (BMI), serum concentration of GGT across all deciles was positively associated with serum concentrations of CRP (P for trend<0.01). For example, adjusted relative risks of serum CRP> or =3.0mg/L by deciles of serum GGT were 1.0, 1.23, 1.40, 1.59, 1.62, 1.61, 2.17, 2.38, 2.45, and 3.41 (P for trend<0.01). This association was consistently observed among all subgroups; Non-Hispanic White, Non-Hispanic Black, Mexican American, men, women, non-drinkers, drinkers, non-smokers, ex-smokers, current smokers, BMI<25, BMI 25-29.9, and BMI> or =30. The strong association of serum GGT and CRP suggest that further studies on cellular and/or serum GGT might help to elucidate the association between oxidative stress and inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-30
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Association between serum gamma-glutamyltransferase and C-reactive protein.
pubmed:affiliation
Department of Preventive Medicine, Division of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Daegu 700 422, Korea. lee_dh@knu.ac.kr
pubmed:publicationType
Journal Article