Source:http://linkedlifedata.com/resource/pubmed/id/15693906
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-2-7
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| pubmed:abstractText |
There is increasing evidence that the development of the fetal immune system can be influenced by environmental exposure in utero. We investigated whether prenatal exposure is associated with a high neonatal total IgE level and sensitization at the age of 1 and 4 yr. Data from 1027 infants were collected in a Dutch birth cohort study (PIAMA study). Total IgE was measured in heel prick blood collected in the first week of life. Sensitization was defined as a specific IgE level in serum of > or =0.35 IU/ml against house dust mite, cat, dog, milk or egg. Logistic regression analysis was performed to study independent relationships between risk factors and a high neonatal total IgE (> or =0.50 IU/ml) or sensitization. A high neonatal total IgE was found in 12.2% of boys and 6.2% of girls. A dog at home during pregnancy was negatively associated with a high neonatal total IgE [odds ratio (95% CI) 0.5 (0.2-1.0)]. A cat at home [OR 0.6 (0.4-1.0) and maternal smoking (OR 0.4 (0.2-1.0)] were negatively associated with sensitization at 12 months, but not at 4 yr. The presence of older siblings, season of birth, birth weight, mode of delivery, gestational age and maternal age were not associated with a high neonatal total IgE or sensitization. The higher total IgE level and prevalence of sensitization at 4 yr in boys compared with girls was only present in children from allergic mothers. Our results suggest a short-lasting protective effect of prenatal exposure to pets on total IgE at birth and early sensitization.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0905-6157
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
10-8
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| pubmed:dateRevised |
2008-5-28
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| pubmed:meshHeading |
pubmed-meshheading:15693906-Age Factors,
pubmed-meshheading:15693906-Animals,
pubmed-meshheading:15693906-Animals, Domestic,
pubmed-meshheading:15693906-Child, Preschool,
pubmed-meshheading:15693906-Cohort Studies,
pubmed-meshheading:15693906-Environmental Exposure,
pubmed-meshheading:15693906-Female,
pubmed-meshheading:15693906-Humans,
pubmed-meshheading:15693906-Hypersensitivity, Immediate,
pubmed-meshheading:15693906-Immunoglobulin E,
pubmed-meshheading:15693906-Infant,
pubmed-meshheading:15693906-Infant, Newborn,
pubmed-meshheading:15693906-Male,
pubmed-meshheading:15693906-Mothers,
pubmed-meshheading:15693906-Netherlands,
pubmed-meshheading:15693906-Odds Ratio,
pubmed-meshheading:15693906-Pregnancy,
pubmed-meshheading:15693906-Prenatal Exposure Delayed Effects,
pubmed-meshheading:15693906-Prospective Studies,
pubmed-meshheading:15693906-Risk Factors,
pubmed-meshheading:15693906-Sex Hormone-Binding Globulin
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| pubmed:year |
2005
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| pubmed:articleTitle |
The effect of prenatal exposure on total IgE at birth and sensitization at twelve months and four years of age: The PIAMA study.
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| pubmed:affiliation |
Department of Epidemiology, University of Groningen, Groningen, The Netherlands. m.kerkhof@med.rug.nl
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|