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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-2-9
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pubmed:abstractText |
Single-nucleotide polymorphisms (SNPs) in the SLC22A4 gene encoding the organic cation transporter OCTN1 have been associated with rheumatoid arthritis (RA) in the Japanese population and with Crohn's disease in a Canadian cohort. The RA-associated and Crohn's disease-associated SNPs include, respectively, an intronic variant (slc2F2) and an exonic variant (1672T). We used a case-control approach to investigate the prevalence of these variants in a Canadian RA cohort and to determine whether RA and Crohn's disease share SLC22A4 susceptibility alleles.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:AmosChristopher ICI,
pubmed-author:GuXiangjunX,
pubmed-author:JohnsonBenB,
pubmed-author:KeystoneEdwardE,
pubmed-author:NewmanBillB,
pubmed-author:OwenJulieJ,
pubmed-author:RubinLaurence ALA,
pubmed-author:SiminovitchKatherine AKA,
pubmed-author:WintleRichard FRF,
pubmed-author:YazdanpanahMehrdadM,
pubmed-author:van OeneMarkM
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
425-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15693005-Adult,
pubmed-meshheading:15693005-Arthritis, Rheumatoid,
pubmed-meshheading:15693005-Asian Continental Ancestry Group,
pubmed-meshheading:15693005-Canada,
pubmed-meshheading:15693005-Case-Control Studies,
pubmed-meshheading:15693005-Crohn Disease,
pubmed-meshheading:15693005-European Continental Ancestry Group,
pubmed-meshheading:15693005-Female,
pubmed-meshheading:15693005-Genetic Predisposition to Disease,
pubmed-meshheading:15693005-Humans,
pubmed-meshheading:15693005-Japan,
pubmed-meshheading:15693005-Male,
pubmed-meshheading:15693005-Membrane Transport Proteins,
pubmed-meshheading:15693005-Middle Aged,
pubmed-meshheading:15693005-Organic Cation Transport Proteins,
pubmed-meshheading:15693005-Polymorphism, Single Nucleotide
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pubmed:year |
2005
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pubmed:articleTitle |
SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population.
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pubmed:affiliation |
University of Toronto and Mount Sinai Hospital Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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