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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-3-7
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pubmed:abstractText |
ALR/Lt, a mouse strain with strong resistance to type 1 diabetes, is closely related to autoimmune type 1 diabetes-prone NOD/Lt mice. ALR pancreatic beta cells are resistant to the beta cell toxin alloxan, combinations of cytotoxic cytokines, and diabetogenic NOD T-cell lines. Reciprocal F1 hybrids between either ALR and NOD or ALR and NON/Lt, showed that alloxan resistance was transmitted to F1 progeny only when ALR was the maternal parent. Here we show that the mitochondrial genome (mtDNA) of ALR mice contributes resistance to diabetes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15692809-Animals,
pubmed-meshheading:15692809-Base Sequence,
pubmed-meshheading:15692809-Crosses, Genetic,
pubmed-meshheading:15692809-DNA, Mitochondrial,
pubmed-meshheading:15692809-DNA Primers,
pubmed-meshheading:15692809-Diabetes Mellitus, Experimental,
pubmed-meshheading:15692809-Diabetes Mellitus, Type 1,
pubmed-meshheading:15692809-Female,
pubmed-meshheading:15692809-Genetic Variation,
pubmed-meshheading:15692809-Immunity, Innate,
pubmed-meshheading:15692809-Kidney,
pubmed-meshheading:15692809-Male,
pubmed-meshheading:15692809-Mice,
pubmed-meshheading:15692809-Mice, Inbred NOD,
pubmed-meshheading:15692809-Mice, Mutant Strains,
pubmed-meshheading:15692809-Mitochondria,
pubmed-meshheading:15692809-Mitochondria, Liver,
pubmed-meshheading:15692809-NADH Dehydrogenase,
pubmed-meshheading:15692809-Polymerase Chain Reaction,
pubmed-meshheading:15692809-Polymorphism, Single Nucleotide
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pubmed:year |
2005
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pubmed:articleTitle |
mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes.
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pubmed:affiliation |
Department of Pediatrics, Diabetes Institute, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3460 5th Ave., Rangos Research Center, Pittsburgh, PA 15213, USA. cem65@pitt.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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