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rdf:type |
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lifeskim:mentions |
umls-concept:C0035696,
umls-concept:C0052850,
umls-concept:C0079189,
umls-concept:C0184512,
umls-concept:C0376526,
umls-concept:C1366876,
umls-concept:C1442514,
umls-concept:C1515877,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1833235,
umls-concept:C1879547
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pubmed:issue |
5710
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pubmed:dateCreated |
2005-2-4
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pubmed:abstractText |
Cytokine production plays a critical role in diseases caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Here we show that a latent KSHV gene product, kaposin B, increases the expression of cytokines by blocking the degradation of their messenger RNAs (mRNAs). Cytokine transcripts are normally unstable because they contain AU-rich elements (AREs) in their 3' noncoding regions that target them for degradation. Kaposin B reverses this instability by binding to and activating the kinase MK2, a target of the p38 mitogen-activated protein kinase signaling pathway and a known inhibitor of ARE-mRNA decay. These findings define an important mechanism linking latent KSHV infection to cytokine production, and also illustrate a distinctive mode by which viruses can selectively modulate mRNA turnover.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
307
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
739-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15692053-Cell Line,
pubmed-meshheading:15692053-Cell Line, Tumor,
pubmed-meshheading:15692053-Cell Nucleus,
pubmed-meshheading:15692053-Cytokines,
pubmed-meshheading:15692053-Cytosol,
pubmed-meshheading:15692053-Enzyme Activation,
pubmed-meshheading:15692053-HeLa Cells,
pubmed-meshheading:15692053-Herpesvirus 8, Human,
pubmed-meshheading:15692053-Humans,
pubmed-meshheading:15692053-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15692053-MAP Kinase Signaling System,
pubmed-meshheading:15692053-Models, Biological,
pubmed-meshheading:15692053-Phosphorylation,
pubmed-meshheading:15692053-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15692053-RNA, Messenger,
pubmed-meshheading:15692053-RNA Stability,
pubmed-meshheading:15692053-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:15692053-Transcription, Genetic,
pubmed-meshheading:15692053-Transfection,
pubmed-meshheading:15692053-Two-Hybrid System Techniques,
pubmed-meshheading:15692053-Viral Proteins,
pubmed-meshheading:15692053-Virus Latency,
pubmed-meshheading:15692053-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Microbiology and Immunology, and Department of Medicine, University of California, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article
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