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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-2-4
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pubmed:abstractText |
Several lines of evidence indicate that abnormalities in the functioning of the central serotonergic system are involved in the pathogenesis of affective illness. A 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR), which influences expression of the serotonin transporter, has been the focus of intensive research since an initial report on an association between 5-HTTLPR and depression-related personality traits. Consistently replicated evidence for an involvement of this polymorphism in the etiology of mood disorders, particularly in major depressive disorder (MDD), remains scant.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3223
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pubmed:author |
pubmed-author:BeckerTimT,
pubmed-author:EckermannAnitaA,
pubmed-author:GrossMagdalenaM,
pubmed-author:HöfelsSusanneS,
pubmed-author:HeidmannVivienV,
pubmed-author:HeunReinhardR,
pubmed-author:HoefgenBarbaraB,
pubmed-author:KölschHeikeH,
pubmed-author:KovalenkoSvetlanaS,
pubmed-author:MaierWolfgangW,
pubmed-author:MettenMartinM,
pubmed-author:NöthenMarkus MMM,
pubmed-author:OhlraunStephanieS,
pubmed-author:ProppingPeterP,
pubmed-author:RietschelMarcellaM,
pubmed-author:SchulzeThomas GTG,
pubmed-author:ZobelAstridA,
pubmed-author:von WiddernOlrikO
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15691525-Adult,
pubmed-meshheading:15691525-Aged,
pubmed-meshheading:15691525-Case-Control Studies,
pubmed-meshheading:15691525-Depressive Disorder, Major,
pubmed-meshheading:15691525-Female,
pubmed-meshheading:15691525-Gene Frequency,
pubmed-meshheading:15691525-Genotype,
pubmed-meshheading:15691525-Humans,
pubmed-meshheading:15691525-Linkage Disequilibrium,
pubmed-meshheading:15691525-Male,
pubmed-meshheading:15691525-Membrane Glycoproteins,
pubmed-meshheading:15691525-Membrane Transport Proteins,
pubmed-meshheading:15691525-Middle Aged,
pubmed-meshheading:15691525-Nerve Tissue Proteins,
pubmed-meshheading:15691525-Phenotype,
pubmed-meshheading:15691525-Polymorphism, Genetic,
pubmed-meshheading:15691525-Serotonin Plasma Membrane Transport Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder.
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pubmed:affiliation |
Department of Psychiatry, University of Bonn, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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