Linked Life Data

15691154

Source:http://linkedlifedata.com/resource/pubmed/id/15691154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-2-4
pubmed:abstractText
Thrombosis among the Thai population is much lower than in western countries. The Thai population is protected to some extent against familial thrombophilia as by the very low prevalence of factor V Leiden, G20210A prothrombin and C677T methylenetetrahydrofolate reductase mutations. The present study reports the prevalence of two mutations of the factor V gene involving the codon for Arg 306 among 500 healthy adult voluntary blood donors (males 285, females 215) and 30 children (boys 20, girls 10) experiencing a total of 36 thrombotic episodes. The blood donors' ages ranged from 18 to 60 years while the children's ages ranged from 9 months to 15 years. The allelic frequencies of the factor V gene mutation of G1091C and A1090G among blood donors were 0% and 0.4%, respectively. Additionally, both mutations were not present in any of the 30 children with thrombosis. The low prevalence of factor V gene mutations in the codon Arg 306 may be relevant to the low rate of thrombosis among the Thai population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0125-1562
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
450-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Absence of factor V Arg306--Thr and low factor V Arg306->Gly mutation prevalence in Thai blood donors.
pubmed:affiliation
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. raajs@mahidol.ac.th
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't