Source:http://linkedlifedata.com/resource/pubmed/id/15687689
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2005-2-2
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| pubmed:abstractText |
TGF-beta is now recognized as an important factor regulating normal mammary gland development as well as breast cancer. In development, TGF-beta regulates branching morphogenesis and differentiation by acting on both epithelial and stromal cells. TGF-beta also regulates apoptosis and matrix remodeling during involution at the end of the pregnancy cycle. TGF-beta has biphasic effects on tumor progression, acting as a tumor suppressor in early stages of cancer and promoting invasion and metastasis at later stages. Furthermore, TGF-beta may play a role in tumor progression through effects on the microenvironment. The tumor promoting effects of TGF-beta may provide a therapeutic target for late stage breast cancer via TGF-beta antagonists like the soluble receptors recently described. Future experiments will uncover the precise mechanisms of TGF-beta action in development and neoplastic disease providing more opportunities for prevention and treatment of breast disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:issn |
0888-6008
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
61-73
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| pubmed:year |
2003
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| pubmed:articleTitle |
TGF-beta in mammary gland development and breast cancer.
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| pubmed:affiliation |
Department of Cell Biology, University of Alabama at Birmingham, 1918 University Blvd., Birmingham, Alabama 35294-0005, USA. rserra@cellbio.bhs.uab.edu
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| pubmed:publicationType |
Journal Article
|