Linked Life Data

1568744

Source:http://linkedlifedata.com/resource/pubmed/id/1568744

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-5-28
pubmed:abstractText
To assess the anatomic relationships between areas of dysplasia and "early" carcinoma, we evaluated histologically the entire mucosal surfaces of seven esophagectomy specimens resected for high-grade dysplasia or early invasive (intramucosal and submucosal) carcinoma. We developed surface area maps and assessed the various degrees of dysplasia or carcinoma at 10 equidistant points. Our analysis shows an equal likelihood of high-grade dysplasia and/or early invasive carcinoma occurring throughout the length of Barrett's epithelium. Foci of carcinoma appear within fields of Barrett's epithelium and adjacent to areas of dysplasia, supporting a dysplasia-carcinoma sequence. The amount of dysplastic epithelium appears related to the surface area of Barrett's epithelium present. However, we found no association between the extent of dysplasia and the likelihood of finding carcinoma. This study supports the current standard of practice for clinical surveillance of patients with Barrett's esophagus by uniformly distributed endoscopic biopsy of the complete length. In addition, the presence of any degree of dysplasia may be an indication for close clinical follow-up.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0046-8177
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
479-82
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Distribution of dysplasias and early invasive carcinoma in Barrett's esophagus.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, UCLA School of Medicine.
pubmed:publicationType
Journal Article