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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-2-2
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pubmed:abstractText |
Cytidine-5'-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine, has shown beneficial effects in a number of CNS injury models including cerebral ischemia. Citicoline is the only neuroprotectant that has proved efficacy in patients with moderate to severe stroke. However, the precise mechanism by which citicoline is neuroprotective is not fully known. The present study was designed to search for mechanisms of citicoline neuroprotective properties using in vivo and in vitro models of brain ischemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Transport System X-AG,
http://linkedlifedata.com/resource/pubmed/chemical/Cytidine Diphosphate Choline,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Transporter 2,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Slc1a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0969-9961
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pubmed:author |
pubmed-author:CárdenasAntonioA,
pubmed-author:CastilloJoséJ,
pubmed-author:DávalosAntoniA,
pubmed-author:Fernández-ToméPazP,
pubmed-author:HurtadoOliviaO,
pubmed-author:LezaJuan CJC,
pubmed-author:LizasoainIgnacioI,
pubmed-author:LorenzoPedroP,
pubmed-author:LozanoRafaelR,
pubmed-author:MoroMaría AMA,
pubmed-author:SánchezVerónicaV,
pubmed-author:SecadesJulio JJJ
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
336-45
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15686962-Adenosine Triphosphate,
pubmed-meshheading:15686962-Amino Acid Transport System X-AG,
pubmed-meshheading:15686962-Animals,
pubmed-meshheading:15686962-Animals, Newborn,
pubmed-meshheading:15686962-Astrocytes,
pubmed-meshheading:15686962-Biological Transport,
pubmed-meshheading:15686962-Brain,
pubmed-meshheading:15686962-Brain Ischemia,
pubmed-meshheading:15686962-Cell Survival,
pubmed-meshheading:15686962-Cells, Cultured,
pubmed-meshheading:15686962-Cerebral Infarction,
pubmed-meshheading:15686962-Coculture Techniques,
pubmed-meshheading:15686962-Cytidine Diphosphate Choline,
pubmed-meshheading:15686962-Cytoprotection,
pubmed-meshheading:15686962-Disease Models, Animal,
pubmed-meshheading:15686962-Excitatory Amino Acid Transporter 2,
pubmed-meshheading:15686962-Glutamate Plasma Membrane Transport Proteins,
pubmed-meshheading:15686962-Glutamic Acid,
pubmed-meshheading:15686962-L-Lactate Dehydrogenase,
pubmed-meshheading:15686962-Male,
pubmed-meshheading:15686962-Nerve Degeneration,
pubmed-meshheading:15686962-Neurons,
pubmed-meshheading:15686962-Neuroprotective Agents,
pubmed-meshheading:15686962-Rats,
pubmed-meshheading:15686962-Rats, Inbred F344,
pubmed-meshheading:15686962-Rats, Wistar,
pubmed-meshheading:15686962-Symporters
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pubmed:year |
2005
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pubmed:articleTitle |
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport.
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pubmed:affiliation |
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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