Source:http://linkedlifedata.com/resource/pubmed/id/15686789
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2005-2-2
|
pubmed:abstractText |
A polymorphism of the human angiotensin-converting enzyme (ACE) gene has been identified in which the insertion (I) rather than the deletion (D) variant is associated with lower circulating and tissue ACE activity. ACE I allele is associated with resistance and endurance performance. Skeletal muscle metabolic efficiency is reduced in patients with heart failure and is improved by ACE inhibition. Profound muscle fatigue is a predominant and debilitating symptom in a proportion or patients with angina and normal coronary arteriograms (ANCA), and we postulated that the gene D allele might be associated with the presence of fatigue in ANCA patients. We studied 33 consecutive patients with typical ANCA who completed a validated fatigue questionnaire, and found an excess of the D allele frequency in patients with the highest fatigue scores compared to those with the lowest (64% vs. 36%; p=0.027).
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0167-5273
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
98
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
339-40
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15686789-Alleles,
pubmed-meshheading:15686789-DNA Transposable Elements,
pubmed-meshheading:15686789-Gene Deletion,
pubmed-meshheading:15686789-Humans,
pubmed-meshheading:15686789-Microvascular Angina,
pubmed-meshheading:15686789-Muscle Fatigue,
pubmed-meshheading:15686789-Peptidyl-Dipeptidase A,
pubmed-meshheading:15686789-Polymorphism, Genetic
|
pubmed:year |
2005
|
pubmed:articleTitle |
Angiotension-converting enzyme gene I/D polymorphism in patients with angina and normal coronary arteriograms.
|
pubmed:publicationType |
Letter,
Research Support, Non-U.S. Gov't
|