Source:http://linkedlifedata.com/resource/pubmed/id/15686726
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2005-2-2
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| pubmed:abstractText |
We retrospectively evaluated the association between risk factors and acute graft-versus-host disease (aGVHD) among 182 beta thalassemia patients who received 73 peripheral blood stem cell (PBSC) or 109 bone marrow transplants from HLA-identical siblings between 1991 and 2003. The relationship between the severity of aGVHD was examined for the following factors: HLA antigens, age, sex, ABO mismatch, sex mismatch (between recipient and donor), thalassemia class, graft source, transplant cell dose, CD3+ cell dose, conditioning regimen, GVHD prophylaxis, neutrophil engraftment duration, and blood product transfusions using univariate and multivariate analyses. Overall 61 (34%) patients developed clinical grade III or grade IV aGVHD. Univariate analysis confirmed an increased risk of severe aGVHD, which was associated with HLA-A11, HLA-A26, and PBSCT (P=.04, .03, and .03, respectively). The risk of aGVHD was reduced in the presence of HLA-A3 (P=.03). Multivariate analysis confirmed the increased risk of aGVHD associated with HLA-A11 (P=.04), HLA-A26 (P=.01), and a short-period neutrophil recovery (P=.009). In this study HLA-A11, HLA-A26, PBSCT, and a short neutrophil engraftment period were probable risk factors and HLA-A3 a probable protective factor associated with severe aGVHD. These data may provide useful guidelines to choose strategies for treatment and prevention.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0041-1345
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
36
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3190-3
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| pubmed:meshHeading |
pubmed-meshheading:15686726-ABO Blood-Group System,
pubmed-meshheading:15686726-Adolescent,
pubmed-meshheading:15686726-Adult,
pubmed-meshheading:15686726-Blood Group Incompatibility,
pubmed-meshheading:15686726-Child,
pubmed-meshheading:15686726-Child, Preschool,
pubmed-meshheading:15686726-Female,
pubmed-meshheading:15686726-Graft vs Host Disease,
pubmed-meshheading:15686726-HLA Antigens,
pubmed-meshheading:15686726-Histocompatibility Testing,
pubmed-meshheading:15686726-Humans,
pubmed-meshheading:15686726-Living Donors,
pubmed-meshheading:15686726-Male,
pubmed-meshheading:15686726-Nuclear Family,
pubmed-meshheading:15686726-Platelet Transfusion,
pubmed-meshheading:15686726-Retrospective Studies,
pubmed-meshheading:15686726-Risk Factors,
pubmed-meshheading:15686726-Stem Cell Transplantation,
pubmed-meshheading:15686726-Thalassemia
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| pubmed:year |
2004
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| pubmed:articleTitle |
Are HLA antigens a risk factor for acute GVHD in thalassemic patients receiving HLA-identical stem cell transplantation?
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| pubmed:affiliation |
Heamatology, Oncology, and BMT Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. mohyeddin@sina.tums.ac.ir
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| pubmed:publicationType |
Journal Article
|