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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-2-1
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pubmed:abstractText |
Previously, we identified 2 functionally relevant polymorphisms in the SLC22A4 / 22A5 genes at the IBD5 locus that alter gene/protein function and comprise a 2-allele haplotype ( SLC22A -TC) associated with increased risk for Crohn's disease (CD). Here we examine the contribution of this susceptibility haplotype alone and in combination with CARD15 variants to CD subphenotypes and to susceptibility to ulcerative colitis (UC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
260-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15685536-Adolescent,
pubmed-meshheading:15685536-Adult,
pubmed-meshheading:15685536-Aged,
pubmed-meshheading:15685536-Base Sequence,
pubmed-meshheading:15685536-Child,
pubmed-meshheading:15685536-Child, Preschool,
pubmed-meshheading:15685536-Colitis, Ulcerative,
pubmed-meshheading:15685536-Crohn Disease,
pubmed-meshheading:15685536-DNA Primers,
pubmed-meshheading:15685536-Female,
pubmed-meshheading:15685536-Gene Expression Regulation,
pubmed-meshheading:15685536-Gene Frequency,
pubmed-meshheading:15685536-Heterozygote Detection,
pubmed-meshheading:15685536-Humans,
pubmed-meshheading:15685536-Jews,
pubmed-meshheading:15685536-Male,
pubmed-meshheading:15685536-Membrane Transport Proteins,
pubmed-meshheading:15685536-Middle Aged,
pubmed-meshheading:15685536-Multigene Family,
pubmed-meshheading:15685536-Organic Cation Transport Proteins,
pubmed-meshheading:15685536-Phenotype
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pubmed:year |
2005
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pubmed:articleTitle |
A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease.
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pubmed:affiliation |
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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